Assessment of the toxicogenic effects and cell death potential of the ester (Z)-methyl 4-((1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)amino)-4-oxobut-2-anoate in combination with cisplatin, cyclophosphamide and doxorubicin

Despite rapid advances in both the early detection and treatment of cancer, the mortality from this disease remains high, which justifies the development of new products that are more selective and effective and have fewer side effects. Accordingly, a novel ester was synthesized that contains two ph...

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Detalles Bibliográficos
Autores principales: Juliano Oliveira, Rodrigo, Pereira, Fabrícia Paniago Ajala Nery, da Silveira, Ingridhy Ostaciana Maia Freitas, de Lima, Ricardo Vieira, Berno, Claudia Rodrigues, Pesarini, João Renato, Antoniolli-Silva, Andréia Conceição Milan Brochado, Monreal, Antônio Carlos Duenhas, Adilson, Beatriz, de Lima, Dênis Pires, Gomes, Roberto da Silva
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Genética 2019
Materias:
Mutagenesis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6726153/
https://www.ncbi.nlm.nih.gov/pubmed/31259359
http://dx.doi.org/10.1590/1678-4685-GMB-2017-0279

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