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Up-regulation of RIP1 and IPS-1 in chronic HBV infected patients

IPS-1 and RIP1 are the main downstream molecules of RIG1 and MDA5, as intracytoplasmic receptors, which are the main receptors involved in recognition of internal and external viral double-stranded RNA. In this project, mRNA levels of IPS-1 and RIP1 were investigated in the peripheral blood immune c...

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Autores principales: Safari-Arababadi, Minoo, Modarressi, Mohammad Hossein, Arababadi, Mohammad Kazemi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Genética 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6726166/
https://www.ncbi.nlm.nih.gov/pubmed/31429854
http://dx.doi.org/10.1590/1678-4685-GMB-2018-0071
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author Safari-Arababadi, Minoo
Modarressi, Mohammad Hossein
Arababadi, Mohammad Kazemi
author_facet Safari-Arababadi, Minoo
Modarressi, Mohammad Hossein
Arababadi, Mohammad Kazemi
author_sort Safari-Arababadi, Minoo
collection PubMed
description IPS-1 and RIP1 are the main downstream molecules of RIG1 and MDA5, as intracytoplasmic receptors, which are the main receptors involved in recognition of internal and external viral double-stranded RNA. In this project, mRNA levels of IPS-1 and RIP1 were investigated in the peripheral blood immune cells of chronic hepatitis B (CHB) patients. IPS-1 and RIP1 mRNA levels were measured in 60 CHB patients and 120 healthy subjects, using RT-qPCR technique. A significant increase in expression levels of IPS-1 and RIP1 was found in patients when compared to healthy individuals. There was no correlation between IPS-1 and RIP1expression levels with the serum levels of hepatitis B e-Antigen (HBeAg) and liver enzymes in patients. Based on the results, it seems that IPS-1 and RIP1 can participate in the induction of low chronic inflammation, which is a main cause of liver cirrhosis and hepatocellular carcinoma.
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spelling pubmed-67261662019-09-12 Up-regulation of RIP1 and IPS-1 in chronic HBV infected patients Safari-Arababadi, Minoo Modarressi, Mohammad Hossein Arababadi, Mohammad Kazemi Genet Mol Biol Human and Medical Genetics IPS-1 and RIP1 are the main downstream molecules of RIG1 and MDA5, as intracytoplasmic receptors, which are the main receptors involved in recognition of internal and external viral double-stranded RNA. In this project, mRNA levels of IPS-1 and RIP1 were investigated in the peripheral blood immune cells of chronic hepatitis B (CHB) patients. IPS-1 and RIP1 mRNA levels were measured in 60 CHB patients and 120 healthy subjects, using RT-qPCR technique. A significant increase in expression levels of IPS-1 and RIP1 was found in patients when compared to healthy individuals. There was no correlation between IPS-1 and RIP1expression levels with the serum levels of hepatitis B e-Antigen (HBeAg) and liver enzymes in patients. Based on the results, it seems that IPS-1 and RIP1 can participate in the induction of low chronic inflammation, which is a main cause of liver cirrhosis and hepatocellular carcinoma. Sociedade Brasileira de Genética 2019-08-19 2019 /pmc/articles/PMC6726166/ /pubmed/31429854 http://dx.doi.org/10.1590/1678-4685-GMB-2018-0071 Text en Copyright © 2019, Sociedade Brasileira de Genética. https://creativecommons.org/licenses/by/4.0/ License information: This is an open-access article distributed under the terms of the Creative Commons Attribution License (type CC-BY), which permits unrestricted use, distribution and reproduction in any medium, provided the original article is properly cited.
spellingShingle Human and Medical Genetics
Safari-Arababadi, Minoo
Modarressi, Mohammad Hossein
Arababadi, Mohammad Kazemi
Up-regulation of RIP1 and IPS-1 in chronic HBV infected patients
title Up-regulation of RIP1 and IPS-1 in chronic HBV infected patients
title_full Up-regulation of RIP1 and IPS-1 in chronic HBV infected patients
title_fullStr Up-regulation of RIP1 and IPS-1 in chronic HBV infected patients
title_full_unstemmed Up-regulation of RIP1 and IPS-1 in chronic HBV infected patients
title_short Up-regulation of RIP1 and IPS-1 in chronic HBV infected patients
title_sort up-regulation of rip1 and ips-1 in chronic hbv infected patients
topic Human and Medical Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6726166/
https://www.ncbi.nlm.nih.gov/pubmed/31429854
http://dx.doi.org/10.1590/1678-4685-GMB-2018-0071
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