A chemical conjugate between HER2-targeting antibody fragment and Pseudomonas exotoxin A fragment demonstrates cytotoxic effects on HER2-expressing breast cancer cells

Conventionally, immunotoxins have been produced as a single polypeptide from fused genes of an antibody fragment and a toxin. In this study, we adopted a unique approach of chemical conjugation of a toxin protein and an antibody fragment. The two genes were separately expressed in Escherichia coli a...

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Detalles Bibliográficos
Autores principales: Lee, Sunju, Park, Sangsu, Nguyen, Minh Tan, Lee, Eunyoung, Kim, Julee, Baek, Sangki, Kim, Chong Jai, Jang, Yeon Jin, Choe, Han
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society for Biochemistry and Molecular Biology 2019
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6726212/
https://www.ncbi.nlm.nih.gov/pubmed/30670149
http://dx.doi.org/10.5483/BMBRep.2019.52.8.250

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6726212/
https://www.ncbi.nlm.nih.gov/pubmed/30670149
http://dx.doi.org/10.5483/BMBRep.2019.52.8.250

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