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Mechanism of the allosteric activation of the ClpP protease machinery by substrates and active-site inhibitors
Coordinated conformational transitions in oligomeric enzymatic complexes modulate function in response to substrates and play a crucial role in enzyme inhibition and activation. Caseinolytic protease (ClpP) is a tetradecameric complex, which has emerged as a drug target against multiple pathogenic b...
| Autores principales: | , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Association for the Advancement of Science
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6726451/ https://www.ncbi.nlm.nih.gov/pubmed/31517045 http://dx.doi.org/10.1126/sciadv.aaw3818 |