Na(+)-H(+) exchanger 1 determines atherosclerotic lesion acidification and promotes atherogenesis

The pH in atherosclerotic lesions varies between individuals. IgE activates macrophage Na(+)-H(+) exchanger (Nhe1) and induces extracellular acidification and cell apoptosis. Here, we show that the pH-sensitive pHrodo probe localizes the acidic regions in atherosclerotic lesions to macrophages, IgE,...

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Detalles Bibliográficos
Autores principales: Liu, Cong-Lin, Zhang, Xian, Liu, Jing, Wang, Yunzhe, Sukhova, Galina K., Wojtkiewicz, Gregory R., Liu, Tianxiao, Tang, Rui, Achilefu, Samuel, Nahrendorf, Matthias, Libby, Peter, Guo, Junli, Zhang, Jin-Ying, Shi, Guo-Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6726618/
https://www.ncbi.nlm.nih.gov/pubmed/31484936
http://dx.doi.org/10.1038/s41467-019-11983-3

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