The transcribed pseudogene RPSAP52 enhances the oncofetal HMGA2-IGF2BP2-RAS axis through LIN28B-dependent and independent let-7 inhibition

One largely unknown question in cell biology is the discrimination between inconsequential and functional transcriptional events with relevant regulatory functions. Here, we find that the oncofetal HMGA2 gene is aberrantly reexpressed in many tumor types together with its antisense transcribed pseud...

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Detalles Bibliográficos
Autores principales: Oliveira-Mateos, Cristina, Sánchez-Castillo, Anaís, Soler, Marta, Obiols-Guardia, Aida, Piñeyro, David, Boque-Sastre, Raquel, Calleja-Cervantes, Maria E., Castro de Moura, Manuel, Martínez-Cardús, Anna, Rubio, Teresa, Pelletier, Joffrey, Martínez-Iniesta, Maria, Herrero-Martín, David, Tirado, Oscar M., Gentilella, Antonio, Villanueva, Alberto, Esteller, Manel, Farré, Lourdes, Guil, Sonia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6726650/
https://www.ncbi.nlm.nih.gov/pubmed/31484926
http://dx.doi.org/10.1038/s41467-019-11910-6

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