Protein prenylation restrains innate immunity by inhibiting Rac1 effector interactions

Rho family proteins are prenylated by geranylgeranyltransferase type I (GGTase-I), which normally target proteins to membranes for GTP-loading. However, conditional deletion of GGTase-I in mouse macrophages increases GTP-loading of Rho proteins, leading to enhanced inflammatory responses and severe...

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Detalles Bibliográficos
Autores principales: Akula, Murali K., Ibrahim, Mohamed X., Ivarsson, Emil G., Khan, Omar M., Kumar, Israiel T., Erlandsson, Malin, Karlsson, Christin, Xu, Xiufeng, Brisslert, Mikael, Brakebusch, Cord, Wang, Donghai, Bokarewa, Maria, Sayin, Volkan I., Bergo, Martin O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6726657/
https://www.ncbi.nlm.nih.gov/pubmed/31484924
http://dx.doi.org/10.1038/s41467-019-11606-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6726657/
https://www.ncbi.nlm.nih.gov/pubmed/31484924
http://dx.doi.org/10.1038/s41467-019-11606-x

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