Overproduction of thrombopoietin by BRAFV600E‐mutated mouse hepatocytes and contribution of thrombopoietin to hepatocarcinogenesis

In hepatocarcinogenesis induced by diethylnitrosamine (DEN) in B6C3F1 mice, the BrafV637E mutation, corresponding to the human BRAFV600E mutation, plays a pivotal role. The livers of transgenic mice with a hepatocyte‐specific human BRAFV600E mutation weighed 4.5 times more than that of normal mice a...

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Detalles Bibliográficos
Autores principales: Tanaka, Hiroki, Horioka, Kie, Yamamoto, Masahiro, Asari, Masaru, Okuda, Katsuhiro, Yamazaki, Kosuke, Shimizu, Keiko, Ogawa, Katsuhiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6726687/
https://www.ncbi.nlm.nih.gov/pubmed/31301081
http://dx.doi.org/10.1111/cas.14130

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