Psychological Resilience Enhances the Orbitofrontal Network in the Elderly With Mild Cognitive Impairment

Background: It has been suggested that maintaining the efficient organization of the brain’s functional connectivity (FC) supports neuroflexibility under neurogenerative stress. This study examined psychological resilience-related FC in 112 older adults with mild cognitive impairment (MCI). Methods:...

Descripción completa

Detalles Bibliográficos
Autores principales: Son, Sang Joon, Park, Bumhee, Choi, Jin Wook, Roh, Hyun Woong, Kim, Na-Rae, Sin, Jae Eun, Kim, Haena, Lim, Hyun Kook, Hong, Chang Hyung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Psychiatry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6726738/
https://www.ncbi.nlm.nih.gov/pubmed/31555158
http://dx.doi.org/10.3389/fpsyt.2019.00615
Descripción
Sumario:Background: It has been suggested that maintaining the efficient organization of the brain’s functional connectivity (FC) supports neuroflexibility under neurogenerative stress. This study examined psychological resilience-related FC in 112 older adults with mild cognitive impairment (MCI). Methods: Using a resting-state functional magnetic resonance imaging (fMRI) approach, we investigated reorganization of the orbitofrontal gyrus (OFG)/amygdala (AMG)/hippocampus (HP)/parahippocampal gyrus (PHG) FC according to the different levels of resilience scale. Results: Compared with the low resilient group, the high resilient group had greater connectivity strengths between the left inferior OFG and right superior OFG (P < 0.05, Bonferroni corrected), between the right inferior OFG and left PHG (P < 0.05, Bonferroni corrected), and between the right middle OFG and left PHG (false discovery rate < 0.05). Conclusion: Psychological resilience may be associated with enhancement of the orbitofrontal network in the elderly with MCI.

Ejemplares similares