Cargando…

Tizanidine hydrochloride exhibits a cytotoxic effect on osteosarcoma cells through the PI3K/AKT signaling pathway

OBJECTIVES: α2-adrenergic receptors are reportedly involved in cancer cell proliferation, invasion, and apoptosis through regulation of diverse molecules, which implies that it contributes to tumor progression. However, the functional significance of α2-adrenergic receptors in osteosarcoma (OS) is u...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xing, Xue-Wu, Sun, Yu-Fu, Zhao, Jun, Pan, Zi-Xiang, Jiang, Wen-Xue
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	SAGE Publications 2019
Materias:	Pre-Clinical Research Reports
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6726809/ https://www.ncbi.nlm.nih.gov/pubmed/31179788 http://dx.doi.org/10.1177/0300060519850395

Ejemplares similares

Optimization of Microemulgel for Tizanidine Hydrochloride
por: Jagdale, Swati, et al.
Publicado: (2020)

RIDR-PI-103, ROS-activated prodrug PI3K inhibitor inhibits cell growth and impairs the PI3K/Akt pathway in BRAF and MEK inhibitor-resistant BRAF-mutant melanoma cells
por: Patel, Hima, et al.
Publicado: (2023)

Isolation and Characterization of a Process Impurity in Tizanidine Hydrochloride
por: Vijayakumar, E. K. S., et al.
Publicado: (2010)

NLRC5 promotes cell migration and invasion by activating the PI3K/AKT signaling pathway in endometrial cancer
por: Fan, Yijun, et al.
Publicado: (2020)

Tizanidine (Hydrochloride) Inhibits A549 Lung Cancer Cell Proliferation and Motility Through Regulating Nischarin
por: Zhao, Liang, et al.
Publicado: (2020)

Cardioprotective effect of IGF-1 against myocardial ischemia/reperfusion injury through activation of PI3K/Akt pathway in rats in vivo
por: Liao, Yaojun, et al.
Publicado: (2019)

Activation of autophagy during farnesyl pyrophosphate synthase inhibition is mediated through PI3K/AKT/mTOR signaling
por: Han, Jie, et al.
Publicado: (2019)

Andrographolide enhanced radiosensitivity by downregulating glycolysis via the inhibition of the PI3K-Akt-mTOR signaling pathway in HCT116 colorectal cancer cells
por: Li, Xiaofei, et al.
Publicado: (2020)

The PI3K/AKT/mTOR pathway regulates autophagy to induce apoptosis of alveolar epithelial cells in chronic obstructive pulmonary disease caused by PM2.5 particulate matter
por: Zhang, Fang, et al.
Publicado: (2020)

GSTA3 regulates TGF-β1-induced renal interstitial fibrosis in NRK-52E cells as a component of the PI3K–Keap1/Nrf2 pathway
por: Xiao, Yun, et al.
Publicado: (2019)

The identification of the anthracycline aclarubicin as an effective cytotoxic agent for pancreatic cancer
por: Brouwer, Thomas P., et al.
Publicado: (2022)

PENK inhibits osteosarcoma cell migration by activating the PI3K/Akt signaling pathway
por: Zhang, Hai-ping, et al.
Publicado: (2020)

Benazepril hydrochloride protects against doxorubicin cardiotoxicity by regulating the PI3K/Akt pathway
por: Zhan, Lan, et al.
Publicado: (2021)

Functional role of MicroRNA/PI3K/AKT axis in osteosarcoma
por: Xiang, Yubo, et al.
Publicado: (2023)

Penehyclidine hydrochloride protects against lipopolysaccharide-induced acute lung injury by promoting the PI3K/Akt pathway
por: Weng, Junting, et al.
Publicado: (2023)

Knockdown of Forkhead box A1 suppresses the tumorigenesis and progression of human colon cancer cells through regulating the phosphatase and tensin homolog/Akt pathway
por: Pan, Jie, et al.
Publicado: (2020)

Proof-of-concept of a laser mounted endoscope for touch-less navigated procedures
por: Kral, Florian, et al.
Publicado: (2013)

In vivo optical signatures of neuronal death in a mouse model of Alzheimer's disease
por: Lin, Alexander J, et al.
Publicado: (2014)

Aerobic training and L-arginine supplement attenuates myocardial infarction-induced kidney and liver injury in rats via reduced oxidative stress
por: Ranjbar, Kamal, et al.
Publicado: (2018)

Biochemical and histological changes in the heart of post-partum rats exposed to Natron
por: Saidu, Yusuf, et al.
Publicado: (2018)

Alantolactone suppresses human osteosarcoma through the PI3K/AKT signaling pathway
por: Zhang, Yong, et al.
Publicado: (2020)

ZCCHC12 promotes the progression of osteosarcoma via PI3K/AKT pathway
por: Cui, Yong, et al.
Publicado: (2022)

Possible involvement of the Hedgehog and PDPK1–Akt pathways in the growth and migration of small-cell lung cancer
por: Tang, Naiwang, et al.
Publicado: (2021)

Identification of plasma microRNA-22 as a marker for the diagnosis, prognosis, and chemosensitivity prediction of osteosarcoma
por: Diao, Zhen-bin, et al.
Publicado: (2020)

NF-kB pathway is involved in microscopic colitis pathogenesis
por: Pisani, Laura Francesca, et al.
Publicado: (2022)

Formulation of tizanidine hydrochloride–loaded provesicular system for improved oral delivery and therapeutic activity employing a 2(3) full factorial design
por: Mohsen, Amira Mohamed, et al.
Publicado: (2022)

MicroRNA-22 mediates the cisplatin resistance of osteosarcoma cells by inhibiting autophagy via the PI3K/Akt/mTOR pathway
por: Meng, Chen-Yang, et al.
Publicado: (2020)

Rhaponticin suppresses osteosarcoma through the inhibition of PI3K-Akt-mTOR pathway
por: Mickymaray, Suresh, et al.
Publicado: (2021)

The inhibitory effect of CTAB on human osteosarcoma through the PI3K/AKT signaling pathway
por: Da, Wacili, et al.
Publicado: (2021)

Management of Tizanidine Withdrawal Syndrome: A Case Report
por: Suárez-Lledó, A, et al.
Publicado: (2018)

Tizanidine Toxicity From Ciprofloxacin: A Cautionary Tale
por: Goyal, Lokesh, et al.
Publicado: (2022)

Identification of crucial genes and pathways associated with prostate cancer in multiple databases
por: Guo, Hanxu, et al.
Publicado: (2021)

Ellagic acid inhibits human colon cancer HCT-116 cells by regulating long noncoding RNAs
por: Zhao, Jinlu, et al.
Publicado: (2023)

Curcumin protects murine lung mesenchymal stem cells from H(2)O(2) by modulating the Akt/Nrf2/HO-1 pathway
por: Ke, Shiwen, et al.
Publicado: (2020)

Overexpression of IGFBP5 Enhances Radiosensitivity Through PI3K-AKT Pathway in Prostate Cancer
por: Chen, Xue, et al.
Publicado: (2020)

Estrogen receptor β exhibited anti-tumor effects on osteosarcoma cells by regulating integrin, IAP, NF-kB/BCL-2 and PI3K/Akt signal pathway
por: Yang, Minfei, et al.
Publicado: (2017)

Curcumin regulates the miR-21/PTEN/Akt pathway and acts in synergy with PD98059 to induce apoptosis of human gastric cancer MGC-803 cells
por: Qiang, Zhanrong, et al.
Publicado: (2019)

Paris polyphylla 26 triggers G2/M phase arrest and induces apoptosis in HepG2 cells via inhibition of the Akt signaling pathway
por: Li, Qiang, et al.
Publicado: (2019)

CHRDL2 promotes osteosarcoma cell proliferation and metastasis through the BMP‐9/PI3K/AKT pathway
por: Chen, Houping, et al.
Publicado: (2021)

The effects of di(2-ethylhexyl) phthalate exposure in women with polycystic ovary syndrome undergoing in vitro fertilization
por: Jin, Yue, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_lf0ruugl3murmdtr0ccc1ukhj5