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CDK12 controls G1/S progression by regulating RNAPII processivity at core DNA replication genes

CDK12 is a kinase associated with elongating RNA polymerase II (RNAPII) and is frequently mutated in cancer. CDK12 depletion reduces the expression of homologous recombination (HR) DNA repair genes, but comprehensive insight into its target genes and cellular processes is lacking. We use a chemical...

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Detalles Bibliográficos
Autores principales:	Chirackal Manavalan, Anil Paul, Pilarova, Kveta, Kluge, Michael, Bartholomeeusen, Koen, Rajecky, Michal, Oppelt, Jan, Khirsariya, Prashant, Paruch, Kamil, Krejci, Lumir, Friedel, Caroline C, Blazek, Dalibor
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2019
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6727028/ https://www.ncbi.nlm.nih.gov/pubmed/31347271 http://dx.doi.org/10.15252/embr.201847592

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