Large Animal Models for Anterior Cruciate Ligament Research

Large animal (non-rodent mammal) models are commonly used in ACL research, but no species is currently considered the gold standard. Important considerations when selecting a large animal model include anatomical differences, the natural course of ACL pathology in that species, and biomechanical dif...

Descripción completa

Detalles Bibliográficos
Autores principales: Bascuñán, Ana Luisa, Biedrzycki, Adam, Banks, Scott A., Lewis, Daniel D., Kim, Stanley E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Veterinary Science
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6727067/
https://www.ncbi.nlm.nih.gov/pubmed/31555675
http://dx.doi.org/10.3389/fvets.2019.00292
_version_ 1783449196988203008
author Bascuñán, Ana Luisa
Biedrzycki, Adam
Banks, Scott A.
Lewis, Daniel D.
Kim, Stanley E.
author_facet Bascuñán, Ana Luisa
Biedrzycki, Adam
Banks, Scott A.
Lewis, Daniel D.
Kim, Stanley E.
author_sort Bascuñán, Ana Luisa
collection PubMed
description Large animal (non-rodent mammal) models are commonly used in ACL research, but no species is currently considered the gold standard. Important considerations when selecting a large animal model include anatomical differences, the natural course of ACL pathology in that species, and biomechanical differences between humans and the chosen model. This article summarizes recent reports related to anatomy, pathology, and biomechanics of the ACL for large animal species (dog, goat, sheep, pig, and rabbit) commonly used in ACL research. Each species has unique features and benefits as well as potential drawbacks, which are highlighted in this review. This information may be useful in the selection process when designing future studies.
format Online
Article
Text
id pubmed-6727067
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-67270672019-09-25 Large Animal Models for Anterior Cruciate Ligament Research Bascuñán, Ana Luisa Biedrzycki, Adam Banks, Scott A. Lewis, Daniel D. Kim, Stanley E. Front Vet Sci Veterinary Science Large animal (non-rodent mammal) models are commonly used in ACL research, but no species is currently considered the gold standard. Important considerations when selecting a large animal model include anatomical differences, the natural course of ACL pathology in that species, and biomechanical differences between humans and the chosen model. This article summarizes recent reports related to anatomy, pathology, and biomechanics of the ACL for large animal species (dog, goat, sheep, pig, and rabbit) commonly used in ACL research. Each species has unique features and benefits as well as potential drawbacks, which are highlighted in this review. This information may be useful in the selection process when designing future studies. Frontiers Media S.A. 2019-08-29 /pmc/articles/PMC6727067/ /pubmed/31555675 http://dx.doi.org/10.3389/fvets.2019.00292 Text en Copyright © 2019 Bascuñán, Biedrzycki, Banks, Lewis and Kim. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Veterinary Science
Bascuñán, Ana Luisa
Biedrzycki, Adam
Banks, Scott A.
Lewis, Daniel D.
Kim, Stanley E.
Large Animal Models for Anterior Cruciate Ligament Research
title Large Animal Models for Anterior Cruciate Ligament Research
title_full Large Animal Models for Anterior Cruciate Ligament Research
title_fullStr Large Animal Models for Anterior Cruciate Ligament Research
title_full_unstemmed Large Animal Models for Anterior Cruciate Ligament Research
title_short Large Animal Models for Anterior Cruciate Ligament Research
title_sort large animal models for anterior cruciate ligament research
topic Veterinary Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6727067/
https://www.ncbi.nlm.nih.gov/pubmed/31555675
http://dx.doi.org/10.3389/fvets.2019.00292
work_keys_str_mv AT bascunananaluisa largeanimalmodelsforanteriorcruciateligamentresearch
AT biedrzyckiadam largeanimalmodelsforanteriorcruciateligamentresearch
AT banksscotta largeanimalmodelsforanteriorcruciateligamentresearch
AT lewisdanield largeanimalmodelsforanteriorcruciateligamentresearch
AT kimstanleye largeanimalmodelsforanteriorcruciateligamentresearch

Ejemplares similares