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A Computational Model of Oxytocin Modulation of Olfactory Recognition Memory
Social recognition in mammals depends on complex interactions between sensory and other brain areas as well as modulatory inputs by specific neuropeptides such as oxytocin (OXT). Social recognition memory specifically has been shown to depend among others on olfactory processing, and can be probed u...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Society for Neuroscience
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6727149/ https://www.ncbi.nlm.nih.gov/pubmed/31399493 http://dx.doi.org/10.1523/ENEURO.0201-19.2019 |
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author | Linster, Christiane Kelsch, Wolfgang |
author_facet | Linster, Christiane Kelsch, Wolfgang |
author_sort | Linster, Christiane |
collection | PubMed |
description | Social recognition in mammals depends on complex interactions between sensory and other brain areas as well as modulatory inputs by specific neuropeptides such as oxytocin (OXT). Social recognition memory specifically has been shown to depend among others on olfactory processing, and can be probed using methods similar to those used when probing non-social odor memory. We here use a computational model of two interconnected olfactory networks in the mouse, the olfactory bulb (OB) and anterior olfactory nucleus, to propose a mechanism for olfactory short-term recognition memory and its modulation in social situations. Based on previous experiments, we propose one early locus for memory to be the OB. During social encounters in mice, pyramidal cells in the anterior olfactory nucleus, themselves driven by olfactory input, are rendered more excitable by OXT release, resulting in stronger feedback to OB local interneurons. This additional input to the OB creates stronger dynamics and improves signal-to-noise ratio of odor responses in the OB proper. As a consequence, mouse social olfactory memories are more strongly encoded and their duration is modulated. |
format | Online Article Text |
id | pubmed-6727149 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Society for Neuroscience |
record_format | MEDLINE/PubMed |
spelling | pubmed-67271492019-09-05 A Computational Model of Oxytocin Modulation of Olfactory Recognition Memory Linster, Christiane Kelsch, Wolfgang eNeuro New Research Social recognition in mammals depends on complex interactions between sensory and other brain areas as well as modulatory inputs by specific neuropeptides such as oxytocin (OXT). Social recognition memory specifically has been shown to depend among others on olfactory processing, and can be probed using methods similar to those used when probing non-social odor memory. We here use a computational model of two interconnected olfactory networks in the mouse, the olfactory bulb (OB) and anterior olfactory nucleus, to propose a mechanism for olfactory short-term recognition memory and its modulation in social situations. Based on previous experiments, we propose one early locus for memory to be the OB. During social encounters in mice, pyramidal cells in the anterior olfactory nucleus, themselves driven by olfactory input, are rendered more excitable by OXT release, resulting in stronger feedback to OB local interneurons. This additional input to the OB creates stronger dynamics and improves signal-to-noise ratio of odor responses in the OB proper. As a consequence, mouse social olfactory memories are more strongly encoded and their duration is modulated. Society for Neuroscience 2019-08-28 /pmc/articles/PMC6727149/ /pubmed/31399493 http://dx.doi.org/10.1523/ENEURO.0201-19.2019 Text en Copyright © 2019 Linster and Kelsch http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. |
spellingShingle | New Research Linster, Christiane Kelsch, Wolfgang A Computational Model of Oxytocin Modulation of Olfactory Recognition Memory |
title | A Computational Model of Oxytocin Modulation of Olfactory Recognition Memory |
title_full | A Computational Model of Oxytocin Modulation of Olfactory Recognition Memory |
title_fullStr | A Computational Model of Oxytocin Modulation of Olfactory Recognition Memory |
title_full_unstemmed | A Computational Model of Oxytocin Modulation of Olfactory Recognition Memory |
title_short | A Computational Model of Oxytocin Modulation of Olfactory Recognition Memory |
title_sort | computational model of oxytocin modulation of olfactory recognition memory |
topic | New Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6727149/ https://www.ncbi.nlm.nih.gov/pubmed/31399493 http://dx.doi.org/10.1523/ENEURO.0201-19.2019 |
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