Generation of dual specific bivalent BiTEs (dbBIspecific T-cell engaging antibodies) for cellular immunotherapy

BACKGROUND: Bispecific T-cell engaging antibodies (BiTES), comprising dual anti-CD3 and anti-tumor antigen scFv fragments, are important therapeutic agents for the treatment of cancer. The dual scFv construct for BiTES requires proper protein folding while their small molecular size leads to rapid k...

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Detalles Bibliográficos
Autores principales: Kujawski, Maciej, Li, Lin, Bhattacharya, Supriyo, Wong, Patty, Lee, Wen-Hui, Williams, Lindsay, Li, Harry, Chea, Junie, Poku, Kofi, Bowles, Nicole, Vaidehi, Nagarajan, Yazaki, Paul, Shively, John E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Technical Advance
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6727398/
https://www.ncbi.nlm.nih.gov/pubmed/31488104
http://dx.doi.org/10.1186/s12885-019-6056-8

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