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(3Z)-5-Chloro-3-(Hydroxyimino)indolin-2-one attenuates hyperglycemia, increased hepatic glycogen content and hepatic damage induced by malathion acute exposure in rats

BACKGROUND: Organophosphorus pesticides (OP’s) are heavily constituted in agriculture, gardens, home and veterinary and although it is useful, there are concerns about the environment, safety and health of human and animals. In this study, we investigated the effects of a new oxime, (3Z)-5-Chloro-3-...

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Autores principales: da Luz Abreu, Edina, Savall, Anne Suély Pinto, Boneberg, Allyson Ardais, Martins, Bianca Barreto, Gervini, Vanessa Carratú, Sampaio, Tuane Bazanella, Fajardo, André Ricardo, Paroul, Natália, Roos, Daniel Henrique, Pinton, Simone
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6727524/
https://www.ncbi.nlm.nih.gov/pubmed/31516541
http://dx.doi.org/10.1186/s12986-019-0374-3
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author da Luz Abreu, Edina
Savall, Anne Suély Pinto
Boneberg, Allyson Ardais
Martins, Bianca Barreto
Gervini, Vanessa Carratú
Sampaio, Tuane Bazanella
Fajardo, André Ricardo
Paroul, Natália
Roos, Daniel Henrique
Pinton, Simone
author_facet da Luz Abreu, Edina
Savall, Anne Suély Pinto
Boneberg, Allyson Ardais
Martins, Bianca Barreto
Gervini, Vanessa Carratú
Sampaio, Tuane Bazanella
Fajardo, André Ricardo
Paroul, Natália
Roos, Daniel Henrique
Pinton, Simone
author_sort da Luz Abreu, Edina
collection PubMed
description BACKGROUND: Organophosphorus pesticides (OP’s) are heavily constituted in agriculture, gardens, home and veterinary and although it is useful, there are concerns about the environment, safety and health of human and animals. In this study, we investigated the effects of a new oxime, (3Z)-5-Chloro-3-(Hydroxyimino)indolin-2-one (OXIME) against the alterations induced by malathion, an OP insecticide, acute exposure on markers of hepatic damage, glucose homeostasis, oxidative stress in rats cholinesterase (ChE) activity in rats. METHODS: Adult male Wistar rats were divided into four groups: Control; Malathion; OXIME; and Malathion+OXIME. Twelve hours after co-treatment with malathion (250 mg/kg, i.p.) and/or OXIME (50 mg/kg, i.g.), the plasma and liver samples were collected for biochemical analyses. RESULTS: The OXIME blocked the increase of plasma markers of hepatic function (AST and ALP) and the enzymatic inhibition of catalase and glutathione reductase in the liver of malathion-treated rats. Moreover, the hepatic cholinesterases inhibition induced by malathion acute exposure was suppressed by OXIME treatment. As assessed, a single dose of OXIME lowered the glycemia levels and hepatic glycogen content enhanced by malathion. CONCLUSIONS: This study suggests promise effects of (3Z)-5-Chloro-3-(Hydroxyimino) indolin-2-one against the hyperglycemia and the hepatic damage induced by malathion acute exposure, as well as its use as a ChE activity reactivator.
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spelling pubmed-67275242019-09-12 (3Z)-5-Chloro-3-(Hydroxyimino)indolin-2-one attenuates hyperglycemia, increased hepatic glycogen content and hepatic damage induced by malathion acute exposure in rats da Luz Abreu, Edina Savall, Anne Suély Pinto Boneberg, Allyson Ardais Martins, Bianca Barreto Gervini, Vanessa Carratú Sampaio, Tuane Bazanella Fajardo, André Ricardo Paroul, Natália Roos, Daniel Henrique Pinton, Simone Nutr Metab (Lond) Research BACKGROUND: Organophosphorus pesticides (OP’s) are heavily constituted in agriculture, gardens, home and veterinary and although it is useful, there are concerns about the environment, safety and health of human and animals. In this study, we investigated the effects of a new oxime, (3Z)-5-Chloro-3-(Hydroxyimino)indolin-2-one (OXIME) against the alterations induced by malathion, an OP insecticide, acute exposure on markers of hepatic damage, glucose homeostasis, oxidative stress in rats cholinesterase (ChE) activity in rats. METHODS: Adult male Wistar rats were divided into four groups: Control; Malathion; OXIME; and Malathion+OXIME. Twelve hours after co-treatment with malathion (250 mg/kg, i.p.) and/or OXIME (50 mg/kg, i.g.), the plasma and liver samples were collected for biochemical analyses. RESULTS: The OXIME blocked the increase of plasma markers of hepatic function (AST and ALP) and the enzymatic inhibition of catalase and glutathione reductase in the liver of malathion-treated rats. Moreover, the hepatic cholinesterases inhibition induced by malathion acute exposure was suppressed by OXIME treatment. As assessed, a single dose of OXIME lowered the glycemia levels and hepatic glycogen content enhanced by malathion. CONCLUSIONS: This study suggests promise effects of (3Z)-5-Chloro-3-(Hydroxyimino) indolin-2-one against the hyperglycemia and the hepatic damage induced by malathion acute exposure, as well as its use as a ChE activity reactivator. BioMed Central 2019-09-05 /pmc/articles/PMC6727524/ /pubmed/31516541 http://dx.doi.org/10.1186/s12986-019-0374-3 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
da Luz Abreu, Edina
Savall, Anne Suély Pinto
Boneberg, Allyson Ardais
Martins, Bianca Barreto
Gervini, Vanessa Carratú
Sampaio, Tuane Bazanella
Fajardo, André Ricardo
Paroul, Natália
Roos, Daniel Henrique
Pinton, Simone
(3Z)-5-Chloro-3-(Hydroxyimino)indolin-2-one attenuates hyperglycemia, increased hepatic glycogen content and hepatic damage induced by malathion acute exposure in rats
title (3Z)-5-Chloro-3-(Hydroxyimino)indolin-2-one attenuates hyperglycemia, increased hepatic glycogen content and hepatic damage induced by malathion acute exposure in rats
title_full (3Z)-5-Chloro-3-(Hydroxyimino)indolin-2-one attenuates hyperglycemia, increased hepatic glycogen content and hepatic damage induced by malathion acute exposure in rats
title_fullStr (3Z)-5-Chloro-3-(Hydroxyimino)indolin-2-one attenuates hyperglycemia, increased hepatic glycogen content and hepatic damage induced by malathion acute exposure in rats
title_full_unstemmed (3Z)-5-Chloro-3-(Hydroxyimino)indolin-2-one attenuates hyperglycemia, increased hepatic glycogen content and hepatic damage induced by malathion acute exposure in rats
title_short (3Z)-5-Chloro-3-(Hydroxyimino)indolin-2-one attenuates hyperglycemia, increased hepatic glycogen content and hepatic damage induced by malathion acute exposure in rats
title_sort (3z)-5-chloro-3-(hydroxyimino)indolin-2-one attenuates hyperglycemia, increased hepatic glycogen content and hepatic damage induced by malathion acute exposure in rats
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6727524/
https://www.ncbi.nlm.nih.gov/pubmed/31516541
http://dx.doi.org/10.1186/s12986-019-0374-3
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