A combination of LMO2 negative and CD38 positive is useful for the diagnosis of Burkitt lymphoma

BACKGROUND: To evaluate the clinical utility of LIM Domain Only 2 (LMO2) negative and CD38 positive in diagnosis of Burkitt lymphoma (BL). METHODS: LMO2 and CD38 expression determined by immunohistochemistry in 75 BL, 12 High-grade B-cell lymphoma, NOS (HGBL,NOS) and 3 Burkitt-like lymphomas with th...

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Autores principales: Liu, Yifei, Bian, Tingting, Zhang, Yanlin, Zheng, Yuanyuan, Zhang, Jianguo, Zhou, Xiaoge, Xie, Jianlan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6727582/
https://www.ncbi.nlm.nih.gov/pubmed/31484540
http://dx.doi.org/10.1186/s13000-019-0876-3
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author Liu, Yifei
Bian, Tingting
Zhang, Yanlin
Zheng, Yuanyuan
Zhang, Jianguo
Zhou, Xiaoge
Xie, Jianlan
author_facet Liu, Yifei
Bian, Tingting
Zhang, Yanlin
Zheng, Yuanyuan
Zhang, Jianguo
Zhou, Xiaoge
Xie, Jianlan
author_sort Liu, Yifei
collection PubMed
description BACKGROUND: To evaluate the clinical utility of LIM Domain Only 2 (LMO2) negative and CD38 positive in diagnosis of Burkitt lymphoma (BL). METHODS: LMO2 and CD38 expression determined by immunohistochemistry in 75 BL, 12 High-grade B-cell lymphoma, NOS (HGBL,NOS) and 3 Burkitt-like lymphomas with the 11q aberration. RESULTS: The sensitivity and specificity of LMO2 negative for detecting BL were 98.67 and 100%, respectively; those of CD38 positive were 98.67 and 66.67%, respectively. The sensitivity and specificity of a combination of both for detecting BL were 97.33 and 100%, respectively. In our study, the combined LMO2 negative and CD38 positive results had a higher area under the curve than either LMO2 negative or CD38 positive alone. CONCLUSIONS: A combination of LMO2 negative and CD38 positive is useful for the diagnosis of Burkitt lymphoma.
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spelling pubmed-67275822019-09-12 A combination of LMO2 negative and CD38 positive is useful for the diagnosis of Burkitt lymphoma Liu, Yifei Bian, Tingting Zhang, Yanlin Zheng, Yuanyuan Zhang, Jianguo Zhou, Xiaoge Xie, Jianlan Diagn Pathol Research BACKGROUND: To evaluate the clinical utility of LIM Domain Only 2 (LMO2) negative and CD38 positive in diagnosis of Burkitt lymphoma (BL). METHODS: LMO2 and CD38 expression determined by immunohistochemistry in 75 BL, 12 High-grade B-cell lymphoma, NOS (HGBL,NOS) and 3 Burkitt-like lymphomas with the 11q aberration. RESULTS: The sensitivity and specificity of LMO2 negative for detecting BL were 98.67 and 100%, respectively; those of CD38 positive were 98.67 and 66.67%, respectively. The sensitivity and specificity of a combination of both for detecting BL were 97.33 and 100%, respectively. In our study, the combined LMO2 negative and CD38 positive results had a higher area under the curve than either LMO2 negative or CD38 positive alone. CONCLUSIONS: A combination of LMO2 negative and CD38 positive is useful for the diagnosis of Burkitt lymphoma. BioMed Central 2019-09-04 /pmc/articles/PMC6727582/ /pubmed/31484540 http://dx.doi.org/10.1186/s13000-019-0876-3 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Liu, Yifei
Bian, Tingting
Zhang, Yanlin
Zheng, Yuanyuan
Zhang, Jianguo
Zhou, Xiaoge
Xie, Jianlan
A combination of LMO2 negative and CD38 positive is useful for the diagnosis of Burkitt lymphoma
title A combination of LMO2 negative and CD38 positive is useful for the diagnosis of Burkitt lymphoma
title_full A combination of LMO2 negative and CD38 positive is useful for the diagnosis of Burkitt lymphoma
title_fullStr A combination of LMO2 negative and CD38 positive is useful for the diagnosis of Burkitt lymphoma
title_full_unstemmed A combination of LMO2 negative and CD38 positive is useful for the diagnosis of Burkitt lymphoma
title_short A combination of LMO2 negative and CD38 positive is useful for the diagnosis of Burkitt lymphoma
title_sort combination of lmo2 negative and cd38 positive is useful for the diagnosis of burkitt lymphoma
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6727582/
https://www.ncbi.nlm.nih.gov/pubmed/31484540
http://dx.doi.org/10.1186/s13000-019-0876-3
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