Regioselective trans-Carboboration of Propargyl Alcohols

[Image: see text] Proper choice of the base allowed trans-diboration of propargyl alcohols with B(2)(pin)(2) to evolve into an exquisitely regioselective procedure for net trans-carboboration. The method is modular as to the newly introduced carbon substituent (aryl, methyl, allyl, benzyl, alkynyl),...

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Autores principales: Jin, Hongming, Fürstner, Alois
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6727597/
https://www.ncbi.nlm.nih.gov/pubmed/30993987
http://dx.doi.org/10.1021/acs.orglett.9b01225
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author Jin, Hongming
Fürstner, Alois
author_facet Jin, Hongming
Fürstner, Alois
author_sort Jin, Hongming
collection PubMed
description [Image: see text] Proper choice of the base allowed trans-diboration of propargyl alcohols with B(2)(pin)(2) to evolve into an exquisitely regioselective procedure for net trans-carboboration. The method is modular as to the newly introduced carbon substituent (aryl, methyl, allyl, benzyl, alkynyl), which is invariably placed distal to the −OH group.
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spelling pubmed-67275972019-09-06 Regioselective trans-Carboboration of Propargyl Alcohols Jin, Hongming Fürstner, Alois Org Lett [Image: see text] Proper choice of the base allowed trans-diboration of propargyl alcohols with B(2)(pin)(2) to evolve into an exquisitely regioselective procedure for net trans-carboboration. The method is modular as to the newly introduced carbon substituent (aryl, methyl, allyl, benzyl, alkynyl), which is invariably placed distal to the −OH group. American Chemical Society 2019-04-17 2019-05-03 /pmc/articles/PMC6727597/ /pubmed/30993987 http://dx.doi.org/10.1021/acs.orglett.9b01225 Text en Copyright © 2019 American Chemical Society This is an open access article published under a Creative Commons Attribution (CC-BY) License (http://pubs.acs.org/page/policy/authorchoice_ccby_termsofuse.html) , which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.
spellingShingle Jin, Hongming
Fürstner, Alois
Regioselective trans-Carboboration of Propargyl Alcohols
title Regioselective trans-Carboboration of Propargyl Alcohols
title_full Regioselective trans-Carboboration of Propargyl Alcohols
title_fullStr Regioselective trans-Carboboration of Propargyl Alcohols
title_full_unstemmed Regioselective trans-Carboboration of Propargyl Alcohols
title_short Regioselective trans-Carboboration of Propargyl Alcohols
title_sort regioselective trans-carboboration of propargyl alcohols
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6727597/
https://www.ncbi.nlm.nih.gov/pubmed/30993987
http://dx.doi.org/10.1021/acs.orglett.9b01225
work_keys_str_mv AT jinhongming regioselectivetranscarboborationofpropargylalcohols
AT furstneralois regioselectivetranscarboborationofpropargylalcohols

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