Considerations for an In Vitro, Cell-Based Testing Platform for Detection of Drug-Induced Inotropic Effects in Early Drug Development. Part 2: Designing and Fabricating Microsystems for Assaying Cardiac Contractility With Physiological Relevance Using Human iPSC-Cardiomyocytes

Contractility of the myocardium engines the pumping function of the heart and is enabled by the collective contractile activity of its muscle cells: cardiomyocytes. The effects of drugs on the contractility of human cardiomyocytes in vitro can provide mechanistic insight that can support the predict...

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Detalles Bibliográficos
Autores principales: Ribeiro, Alexandre J. S., Guth, Brian D., Engwall, Michael, Eldridge, Sandy, Foley, C. Michael, Guo, Liang, Gintant, Gary, Koerner, John, Parish, Stanley T., Pierson, Jennifer B., Brock, Mathew, Chaudhary, Khuram W., Kanda, Yasunari, Berridge, Brian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6727630/
https://www.ncbi.nlm.nih.gov/pubmed/31555128
http://dx.doi.org/10.3389/fphar.2019.00934

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