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Cytosolic translational responses differ under conditions of severe short-term and long-term mitochondrial stress

Previous studies demonstrated that cells inhibit protein synthesis as a compensatory mechanism for mitochondrial dysfunction. Protein synthesis can be attenuated by 1) the inhibition of mTOR kinase, which results in a decrease in the phosphorylation of S6K1 and 4E-BP1 proteins, and 2) an increase in...

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Detalles Bibliográficos
Autores principales: Samluk, Lukasz, Urbanska, Malgorzata, Kisielewska, Katarzyna, Mohanraj, Karthik, Kim, Min-Ji, Machnicka, Katarzyna, Liszewska, Ewa, Jaworski, Jacek, Chacinska, Agnieszka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6727742/
https://www.ncbi.nlm.nih.gov/pubmed/31116686
http://dx.doi.org/10.1091/mbc.E18-10-0628