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Cytoskeletal proteins in the cell nucleus: a special nuclear actin perspective
The emerging role of cytoskeletal proteins in the cell nucleus has become a new frontier in cell biology. Actin and actin-binding proteins regulate chromatin and gene expression, but importantly they are beginning to be essential players in genome organization. These actin-based functions contribute...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The American Society for Cell Biology
2019
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6727747/ https://www.ncbi.nlm.nih.gov/pubmed/31306096 http://dx.doi.org/10.1091/mbc.E18-10-0645 |
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author | Percipalle, Piergiorgio Vartiainen, Maria |
author_facet | Percipalle, Piergiorgio Vartiainen, Maria |
author_sort | Percipalle, Piergiorgio |
collection | PubMed |
description | The emerging role of cytoskeletal proteins in the cell nucleus has become a new frontier in cell biology. Actin and actin-binding proteins regulate chromatin and gene expression, but importantly they are beginning to be essential players in genome organization. These actin-based functions contribute to genome stability and integrity while affecting DNA replication and global transcription patterns. This is likely to occur through interactions of actin with nuclear components including nuclear lamina and subnuclear organelles. An exciting future challenge is to understand how these actin-based genome-wide mechanisms may regulate development and differentiation by interfering with the mechanical properties of the cell nucleus and how regulated actin polymerization plays a role in maintaining nuclear architecture. With a special focus on actin, here we summarize how cytoskeletal proteins operate in the nucleus and how they may be important to consolidate nuclear architecture for sustained gene expression or silencing. |
format | Online Article Text |
id | pubmed-6727747 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | The American Society for Cell Biology |
record_format | MEDLINE/PubMed |
spelling | pubmed-67277472019-09-30 Cytoskeletal proteins in the cell nucleus: a special nuclear actin perspective Percipalle, Piergiorgio Vartiainen, Maria Mol Biol Cell Perspectives The emerging role of cytoskeletal proteins in the cell nucleus has become a new frontier in cell biology. Actin and actin-binding proteins regulate chromatin and gene expression, but importantly they are beginning to be essential players in genome organization. These actin-based functions contribute to genome stability and integrity while affecting DNA replication and global transcription patterns. This is likely to occur through interactions of actin with nuclear components including nuclear lamina and subnuclear organelles. An exciting future challenge is to understand how these actin-based genome-wide mechanisms may regulate development and differentiation by interfering with the mechanical properties of the cell nucleus and how regulated actin polymerization plays a role in maintaining nuclear architecture. With a special focus on actin, here we summarize how cytoskeletal proteins operate in the nucleus and how they may be important to consolidate nuclear architecture for sustained gene expression or silencing. The American Society for Cell Biology 2019-07-15 /pmc/articles/PMC6727747/ /pubmed/31306096 http://dx.doi.org/10.1091/mbc.E18-10-0645 Text en © 2019 Percipalle and Vartiainen “ASCB®,” “The American Society for Cell Biology®,” and “Molecular Biology of the Cell®” are registered trademarks of The American Society for Cell Biology. http://creativecommons.org/licenses/by-nc-sa/3.0 This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License. |
spellingShingle | Perspectives Percipalle, Piergiorgio Vartiainen, Maria Cytoskeletal proteins in the cell nucleus: a special nuclear actin perspective |
title | Cytoskeletal proteins in the cell nucleus: a special nuclear actin perspective |
title_full | Cytoskeletal proteins in the cell nucleus: a special nuclear actin perspective |
title_fullStr | Cytoskeletal proteins in the cell nucleus: a special nuclear actin perspective |
title_full_unstemmed | Cytoskeletal proteins in the cell nucleus: a special nuclear actin perspective |
title_short | Cytoskeletal proteins in the cell nucleus: a special nuclear actin perspective |
title_sort | cytoskeletal proteins in the cell nucleus: a special nuclear actin perspective |
topic | Perspectives |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6727747/ https://www.ncbi.nlm.nih.gov/pubmed/31306096 http://dx.doi.org/10.1091/mbc.E18-10-0645 |
work_keys_str_mv | AT percipallepiergiorgio cytoskeletalproteinsinthecellnucleusaspecialnuclearactinperspective AT vartiainenmaria cytoskeletalproteinsinthecellnucleusaspecialnuclearactinperspective |