VCP/p97 controls signals of the ERK1/2 pathway transmitted via the Shoc2 scaffolding complex: novel insights into IBMPFD pathology

Valosin-containing protein (VCP), also named p97, is an essential hexameric AAA+ ATPase with diverse functions in the ubiquitin system. Here we demonstrate that VCP is critical in controlling signals transmitted via the essential Shoc2-ERK1/2 signaling axis. The ATPase activity of VCP modulates the...

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Detalles Bibliográficos
Autores principales: Jang, HyeIn, Jang, Eun Ryoung, Wilson, Patricia G., Anderson, Daniel, Galperin, Emilia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2019
Materias:
Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6727759/
https://www.ncbi.nlm.nih.gov/pubmed/31091164
http://dx.doi.org/10.1091/mbc.E19-03-0144

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