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Domain-specific mechanical modulation of VWF–ADAMTS13 interaction

Hemodynamic forces activate the Von Willebrand factor (VWF) and facilitate its cleavage by a disintegrin and metalloprotease with thrombospondin motifs-13 (ADAMTS13), reducing the adhesive activity of VWF. Biochemical assays have mapped the binding sites on both molecules. However, these assays requ...

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Detalles Bibliográficos
Autores principales:	Li, Zhenhai, Lin, Jiangguo, Sulchek, Todd, Cruz, Miguel A., Wu, Jianhua, Dong, Jing-fei, Zhu, Cheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Cell Biology 2019
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6727775/ https://www.ncbi.nlm.nih.gov/pubmed/31067148 http://dx.doi.org/10.1091/mbc.E19-01-0021

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