From medications to surgery: advances in the treatment of motor complications in Parkinson’s disease

Motor complications are responsible for the large burden of disability and poor quality of life in Parkinson’s disease (PD). The pulsatile nature of stimulation with oral dopaminergic therapies due to relatively short pharmacokinetic profiles and dysfunctional gastrointestinal absorption have been a...

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Detalles Bibliográficos
Autores principales: Nagao, Kanae Jennifer, Patel, Neepa J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioExcel Publishing Ltd 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6727789/
https://www.ncbi.nlm.nih.gov/pubmed/31516532
http://dx.doi.org/10.7573/dic.212592
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author Nagao, Kanae Jennifer
Patel, Neepa J
author_facet Nagao, Kanae Jennifer
Patel, Neepa J
author_sort Nagao, Kanae Jennifer
collection PubMed
description Motor complications are responsible for the large burden of disability and poor quality of life in Parkinson’s disease (PD). The pulsatile nature of stimulation with oral dopaminergic therapies due to relatively short pharmacokinetic profiles and dysfunctional gastrointestinal absorption have been attributed to the development of PD motor complications. In this review, we will provide an overview of the pharmacologic and surgical therapies currently available and under investigation for the treatment of motor fluctuations and dyskinesia.
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spelling pubmed-67277892019-09-12 From medications to surgery: advances in the treatment of motor complications in Parkinson’s disease Nagao, Kanae Jennifer Patel, Neepa J Drugs Context Review Motor complications are responsible for the large burden of disability and poor quality of life in Parkinson’s disease (PD). The pulsatile nature of stimulation with oral dopaminergic therapies due to relatively short pharmacokinetic profiles and dysfunctional gastrointestinal absorption have been attributed to the development of PD motor complications. In this review, we will provide an overview of the pharmacologic and surgical therapies currently available and under investigation for the treatment of motor fluctuations and dyskinesia. BioExcel Publishing Ltd 2019-08-13 /pmc/articles/PMC6727789/ /pubmed/31516532 http://dx.doi.org/10.7573/dic.212592 Text en Copyright © 2019 Nagao KJ, Patel NJ Published by Drugs in Context under Creative Commons License Deed CC BY NC ND 4.0 which allows anyone to copy, distribute, and transmit the article provided it is properly attributed in the manner specified below. No commercial use without permission.
spellingShingle Review
Nagao, Kanae Jennifer
Patel, Neepa J
From medications to surgery: advances in the treatment of motor complications in Parkinson’s disease
title From medications to surgery: advances in the treatment of motor complications in Parkinson’s disease
title_full From medications to surgery: advances in the treatment of motor complications in Parkinson’s disease
title_fullStr From medications to surgery: advances in the treatment of motor complications in Parkinson’s disease
title_full_unstemmed From medications to surgery: advances in the treatment of motor complications in Parkinson’s disease
title_short From medications to surgery: advances in the treatment of motor complications in Parkinson’s disease
title_sort from medications to surgery: advances in the treatment of motor complications in parkinson’s disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6727789/
https://www.ncbi.nlm.nih.gov/pubmed/31516532
http://dx.doi.org/10.7573/dic.212592
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