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Functional Scaffolding for Brain Implants: Engineered Neuronal Network by Microfabrication and iPSC Technology

Neuroengineering methods can be effectively used in the design of new approaches to treat central nervous system and brain injury caused by neurotrauma, ischemia, or neurodegenerative disorders. During the last decade, significant results were achieved in the field of implant (scaffold) development...

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Autores principales: Shimba, Kenta, Chang, Chih-Hsiang, Asahina, Takahiro, Moriya, Fumika, Kotani, Kiyoshi, Jimbo, Yasuhiko, Gladkov, Arseniy, Antipova, Oksana, Pigareva, Yana, Kolpakov, Vladimir, Mukhina, Irina, Kazantsev, Victor, Pimashkin, Alexey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6727854/
https://www.ncbi.nlm.nih.gov/pubmed/31555074
http://dx.doi.org/10.3389/fnins.2019.00890
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author Shimba, Kenta
Chang, Chih-Hsiang
Asahina, Takahiro
Moriya, Fumika
Kotani, Kiyoshi
Jimbo, Yasuhiko
Gladkov, Arseniy
Antipova, Oksana
Pigareva, Yana
Kolpakov, Vladimir
Mukhina, Irina
Kazantsev, Victor
Pimashkin, Alexey
author_facet Shimba, Kenta
Chang, Chih-Hsiang
Asahina, Takahiro
Moriya, Fumika
Kotani, Kiyoshi
Jimbo, Yasuhiko
Gladkov, Arseniy
Antipova, Oksana
Pigareva, Yana
Kolpakov, Vladimir
Mukhina, Irina
Kazantsev, Victor
Pimashkin, Alexey
author_sort Shimba, Kenta
collection PubMed
description Neuroengineering methods can be effectively used in the design of new approaches to treat central nervous system and brain injury caused by neurotrauma, ischemia, or neurodegenerative disorders. During the last decade, significant results were achieved in the field of implant (scaffold) development using various biocompatible and biodegradable materials carrying neuronal cells for implantation into the injury site of the brain to repair its function. Neurons derived from animal or human induced pluripotent stem (iPS) cells are expected to be an ideal cell source, and induction methods for specific cell types have been actively studied to improve efficacy and specificity. A critical goal of neuro-regeneration is structural and functional restoration of the injury site. The target treatment area has heterogeneous and complex network topology with various types of cells that need to be restored with similar neuronal network structure to recover correct functionality. However, current scaffold-based technology for brain implants operates with homogeneous neuronal cell distribution, which limits recovery in the damaged area of the brain and prevents a return to fully functional biological tissue. In this study, we present a neuroengineering concept for designing a neural circuit with a pre-defined unidirectional network architecture that provides a balance of excitation/inhibition in the scaffold to form tissue similar to that in the injured area using various types of iPS cells. Such tissue will mimic the surrounding niche in the injured site and will morphologically and topologically integrate into the brain, recovering lost function.
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spelling pubmed-67278542019-09-25 Functional Scaffolding for Brain Implants: Engineered Neuronal Network by Microfabrication and iPSC Technology Shimba, Kenta Chang, Chih-Hsiang Asahina, Takahiro Moriya, Fumika Kotani, Kiyoshi Jimbo, Yasuhiko Gladkov, Arseniy Antipova, Oksana Pigareva, Yana Kolpakov, Vladimir Mukhina, Irina Kazantsev, Victor Pimashkin, Alexey Front Neurosci Neuroscience Neuroengineering methods can be effectively used in the design of new approaches to treat central nervous system and brain injury caused by neurotrauma, ischemia, or neurodegenerative disorders. During the last decade, significant results were achieved in the field of implant (scaffold) development using various biocompatible and biodegradable materials carrying neuronal cells for implantation into the injury site of the brain to repair its function. Neurons derived from animal or human induced pluripotent stem (iPS) cells are expected to be an ideal cell source, and induction methods for specific cell types have been actively studied to improve efficacy and specificity. A critical goal of neuro-regeneration is structural and functional restoration of the injury site. The target treatment area has heterogeneous and complex network topology with various types of cells that need to be restored with similar neuronal network structure to recover correct functionality. However, current scaffold-based technology for brain implants operates with homogeneous neuronal cell distribution, which limits recovery in the damaged area of the brain and prevents a return to fully functional biological tissue. In this study, we present a neuroengineering concept for designing a neural circuit with a pre-defined unidirectional network architecture that provides a balance of excitation/inhibition in the scaffold to form tissue similar to that in the injured area using various types of iPS cells. Such tissue will mimic the surrounding niche in the injured site and will morphologically and topologically integrate into the brain, recovering lost function. Frontiers Media S.A. 2019-08-29 /pmc/articles/PMC6727854/ /pubmed/31555074 http://dx.doi.org/10.3389/fnins.2019.00890 Text en Copyright © 2019 Shimba, Chang, Asahina, Moriya, Kotani, Jimbo, Gladkov, Antipova, Pigareva, Kolpakov, Mukhina, Kazantsev and Pimashkin. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Shimba, Kenta
Chang, Chih-Hsiang
Asahina, Takahiro
Moriya, Fumika
Kotani, Kiyoshi
Jimbo, Yasuhiko
Gladkov, Arseniy
Antipova, Oksana
Pigareva, Yana
Kolpakov, Vladimir
Mukhina, Irina
Kazantsev, Victor
Pimashkin, Alexey
Functional Scaffolding for Brain Implants: Engineered Neuronal Network by Microfabrication and iPSC Technology
title Functional Scaffolding for Brain Implants: Engineered Neuronal Network by Microfabrication and iPSC Technology
title_full Functional Scaffolding for Brain Implants: Engineered Neuronal Network by Microfabrication and iPSC Technology
title_fullStr Functional Scaffolding for Brain Implants: Engineered Neuronal Network by Microfabrication and iPSC Technology
title_full_unstemmed Functional Scaffolding for Brain Implants: Engineered Neuronal Network by Microfabrication and iPSC Technology
title_short Functional Scaffolding for Brain Implants: Engineered Neuronal Network by Microfabrication and iPSC Technology
title_sort functional scaffolding for brain implants: engineered neuronal network by microfabrication and ipsc technology
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6727854/
https://www.ncbi.nlm.nih.gov/pubmed/31555074
http://dx.doi.org/10.3389/fnins.2019.00890
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