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Impact of chronic kidney disease on mortality: A nationwide cohort study

BACKGROUND: Mortality is higher in patients with chronic kidney disease (CKD) than in the general population, but little information is available on CKD-related mortality that is representative of the Korean population. Our objective was to investigate mortality risk in Korean patients with CKD. MET...

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Autores principales: Kim, Kyeong Min, Oh, Hyung Jung, Choi, Hyung Yun, Lee, Hajeong, Ryu, Dong-Ryeol
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society of Nephrology 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6727899/
https://www.ncbi.nlm.nih.gov/pubmed/31382730
http://dx.doi.org/10.23876/j.krcp.18.0128
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author Kim, Kyeong Min
Oh, Hyung Jung
Choi, Hyung Yun
Lee, Hajeong
Ryu, Dong-Ryeol
author_facet Kim, Kyeong Min
Oh, Hyung Jung
Choi, Hyung Yun
Lee, Hajeong
Ryu, Dong-Ryeol
author_sort Kim, Kyeong Min
collection PubMed
description BACKGROUND: Mortality is higher in patients with chronic kidney disease (CKD) than in the general population, but little information is available on CKD-related mortality that is representative of the Korean population. Our objective was to investigate mortality risk in Korean patients with CKD. METHODS: We identified patients with incident CKD who had not undergone dialysis or kidney transplantation between January 1, 2003 and December 31, 2007 in Korea using the database of the Korean National Health Insurance Service-National Sample Cohort, and stratified the population into the following three groups: group 1 (n = 1,473), controls; group 2 (n = 2,212), patients with diabetes or hypertension, but without CKD; and group 3 (n = 2,212), patients with CKD. We then monitored them for all-cause mortality until December 2013. RESULTS: A total of 1,473 patients were included in this analysis. During the follow-up period, 941 patients in group 3 died (134 deaths/1,000 person-years) compared with 550 deaths in the group 2 (34 deaths/1,000 person-years) and 459 deaths in group 1 (30 deaths/1,000 person-years). The rate ratio for mortality rate was 4.5, and the hazard ratio for mortality was 4.88 (95% confidence interval [CI], 4.36–5.47, P < 0.001) in patients in group 3 compared with age- and sex-matched controls (group 1). The rate ratio for mortality rate was 4.0, and the hazard ratio for mortality was 4.36 (95% CI, 3.92–4.85, P < 0.001) in patients in group 3 compared with patients in group 2. CONCLUSION: In this nationally representative sample cohort, excess mortality was observed in Korean patients with incident CKD.
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spelling pubmed-67278992019-09-09 Impact of chronic kidney disease on mortality: A nationwide cohort study Kim, Kyeong Min Oh, Hyung Jung Choi, Hyung Yun Lee, Hajeong Ryu, Dong-Ryeol Kidney Res Clin Pract Original Article BACKGROUND: Mortality is higher in patients with chronic kidney disease (CKD) than in the general population, but little information is available on CKD-related mortality that is representative of the Korean population. Our objective was to investigate mortality risk in Korean patients with CKD. METHODS: We identified patients with incident CKD who had not undergone dialysis or kidney transplantation between January 1, 2003 and December 31, 2007 in Korea using the database of the Korean National Health Insurance Service-National Sample Cohort, and stratified the population into the following three groups: group 1 (n = 1,473), controls; group 2 (n = 2,212), patients with diabetes or hypertension, but without CKD; and group 3 (n = 2,212), patients with CKD. We then monitored them for all-cause mortality until December 2013. RESULTS: A total of 1,473 patients were included in this analysis. During the follow-up period, 941 patients in group 3 died (134 deaths/1,000 person-years) compared with 550 deaths in the group 2 (34 deaths/1,000 person-years) and 459 deaths in group 1 (30 deaths/1,000 person-years). The rate ratio for mortality rate was 4.5, and the hazard ratio for mortality was 4.88 (95% confidence interval [CI], 4.36–5.47, P < 0.001) in patients in group 3 compared with age- and sex-matched controls (group 1). The rate ratio for mortality rate was 4.0, and the hazard ratio for mortality was 4.36 (95% CI, 3.92–4.85, P < 0.001) in patients in group 3 compared with patients in group 2. CONCLUSION: In this nationally representative sample cohort, excess mortality was observed in Korean patients with incident CKD. Korean Society of Nephrology 2019-09 2019-09-30 /pmc/articles/PMC6727899/ /pubmed/31382730 http://dx.doi.org/10.23876/j.krcp.18.0128 Text en Copyright © 2019 by The Korean Society of Nephrology This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Kim, Kyeong Min
Oh, Hyung Jung
Choi, Hyung Yun
Lee, Hajeong
Ryu, Dong-Ryeol
Impact of chronic kidney disease on mortality: A nationwide cohort study
title Impact of chronic kidney disease on mortality: A nationwide cohort study
title_full Impact of chronic kidney disease on mortality: A nationwide cohort study
title_fullStr Impact of chronic kidney disease on mortality: A nationwide cohort study
title_full_unstemmed Impact of chronic kidney disease on mortality: A nationwide cohort study
title_short Impact of chronic kidney disease on mortality: A nationwide cohort study
title_sort impact of chronic kidney disease on mortality: a nationwide cohort study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6727899/
https://www.ncbi.nlm.nih.gov/pubmed/31382730
http://dx.doi.org/10.23876/j.krcp.18.0128
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