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Diagnostic Capability of 3D Peripapillary Retinal Volume for Glaucoma Using Optical Coherence Tomography Customized Software

PRÉCIS: The diagnostic capability of peripapillary retinal volume is similar to peripapillary retinal nerve fiber layer thickness for diagnosing glaucoma, but with fewer artifacts. PURPOSE: To compare the diagnostic capability of 3-dimensional peripapillary retinal volume (RV) versus 2-dimensional p...

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Autores principales: Liu, Yingna, Jassim, Firas, Braaf, Boy, Khoueir, Ziad, Poon, Linda Yi-Chieh, Ben-David, Geulah S., Papadogeorgou, Georgia, Tsikata, Edem, Simavli, Huseyin, Que, Christian, Lee, Ramon, Shieh, Eric, Vakoc, Benjamin J., Bouma, Brett E., de Boer, Johannes F., Chen, Teresa C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health, Inc 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6727946/
https://www.ncbi.nlm.nih.gov/pubmed/31180936
http://dx.doi.org/10.1097/IJG.0000000000001291
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author Liu, Yingna
Jassim, Firas
Braaf, Boy
Khoueir, Ziad
Poon, Linda Yi-Chieh
Ben-David, Geulah S.
Papadogeorgou, Georgia
Tsikata, Edem
Simavli, Huseyin
Que, Christian
Lee, Ramon
Shieh, Eric
Vakoc, Benjamin J.
Bouma, Brett E.
de Boer, Johannes F.
Chen, Teresa C.
author_facet Liu, Yingna
Jassim, Firas
Braaf, Boy
Khoueir, Ziad
Poon, Linda Yi-Chieh
Ben-David, Geulah S.
Papadogeorgou, Georgia
Tsikata, Edem
Simavli, Huseyin
Que, Christian
Lee, Ramon
Shieh, Eric
Vakoc, Benjamin J.
Bouma, Brett E.
de Boer, Johannes F.
Chen, Teresa C.
author_sort Liu, Yingna
collection PubMed
description PRÉCIS: The diagnostic capability of peripapillary retinal volume is similar to peripapillary retinal nerve fiber layer thickness for diagnosing glaucoma, but with fewer artifacts. PURPOSE: To compare the diagnostic capability of 3-dimensional peripapillary retinal volume (RV) versus 2-dimensional peripapillary retinal nerve fiber layer (RNFL) thickness for open-angle glaucoma. PATIENTS AND METHODS: A retrospective cross-sectional analysis was conducted. A total of 180 subjects (113 open-angle glaucoma, 67 normal participants) had spectral domain optical coherence tomography volume scans and RNFL thickness measurements. Peripapillary RV values were calculated using a custom-designed program with 4 circumpapillary annuli (CA): CA1 had circle diameters of 2.5 and 3.5 mm; CA2, 3 and 4 mm; CA3, 3.5 and 4.5 mm; and CA4, 4 and 5 mm. Area under the receiver operating characteristic curves were calculated for global, quadrant, and octant regions for RV (CA1 to CA4) and RNFL thickness. Pair-wise comparisons were conducted. Artifacts rates were determined. RESULTS: Mean age was 62.7±15.4 years, and 47.8% (86/180) were male. Among RV measurements, best diagnostic performances were for the smallest 2 annuli for inferior RV (CA1: 0.964, CA2: 0.955). Of the 4 annuli, CA1 had the highest diagnostic performance. Of specific regions, the inferior RV quadrant had the highest performance across CA1 to CA4. Peripapillary RV had similar diagnostic capability compared with RNFL thickness (P>0.05). The artifact rate per B-scan for RV was 6.0%, which was significantly lower compared with 2-dimensional RNFL thickness in the same patient population (32.2%, P<0.0001). CONCLUSIONS: The diagnostic capability of RV is similar to RNFL thickness for perimetric open-angle glaucoma, but RV had fewer artifacts compared with RNFL thickness.
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spelling pubmed-67279462019-10-02 Diagnostic Capability of 3D Peripapillary Retinal Volume for Glaucoma Using Optical Coherence Tomography Customized Software Liu, Yingna Jassim, Firas Braaf, Boy Khoueir, Ziad Poon, Linda Yi-Chieh Ben-David, Geulah S. Papadogeorgou, Georgia Tsikata, Edem Simavli, Huseyin Que, Christian Lee, Ramon Shieh, Eric Vakoc, Benjamin J. Bouma, Brett E. de Boer, Johannes F. Chen, Teresa C. J Glaucoma Original Studies PRÉCIS: The diagnostic capability of peripapillary retinal volume is similar to peripapillary retinal nerve fiber layer thickness for diagnosing glaucoma, but with fewer artifacts. PURPOSE: To compare the diagnostic capability of 3-dimensional peripapillary retinal volume (RV) versus 2-dimensional peripapillary retinal nerve fiber layer (RNFL) thickness for open-angle glaucoma. PATIENTS AND METHODS: A retrospective cross-sectional analysis was conducted. A total of 180 subjects (113 open-angle glaucoma, 67 normal participants) had spectral domain optical coherence tomography volume scans and RNFL thickness measurements. Peripapillary RV values were calculated using a custom-designed program with 4 circumpapillary annuli (CA): CA1 had circle diameters of 2.5 and 3.5 mm; CA2, 3 and 4 mm; CA3, 3.5 and 4.5 mm; and CA4, 4 and 5 mm. Area under the receiver operating characteristic curves were calculated for global, quadrant, and octant regions for RV (CA1 to CA4) and RNFL thickness. Pair-wise comparisons were conducted. Artifacts rates were determined. RESULTS: Mean age was 62.7±15.4 years, and 47.8% (86/180) were male. Among RV measurements, best diagnostic performances were for the smallest 2 annuli for inferior RV (CA1: 0.964, CA2: 0.955). Of the 4 annuli, CA1 had the highest diagnostic performance. Of specific regions, the inferior RV quadrant had the highest performance across CA1 to CA4. Peripapillary RV had similar diagnostic capability compared with RNFL thickness (P>0.05). The artifact rate per B-scan for RV was 6.0%, which was significantly lower compared with 2-dimensional RNFL thickness in the same patient population (32.2%, P<0.0001). CONCLUSIONS: The diagnostic capability of RV is similar to RNFL thickness for perimetric open-angle glaucoma, but RV had fewer artifacts compared with RNFL thickness. Wolters Kluwer Health, Inc 2019-08 2019-08-01 /pmc/articles/PMC6727946/ /pubmed/31180936 http://dx.doi.org/10.1097/IJG.0000000000001291 Text en Copyright © 2019 The Author(s). Published by Wolters Kluwer Health, Inc. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (http://creativecommons.org/licenses/by-nc-nd/4.0/) (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0/
spellingShingle Original Studies
Liu, Yingna
Jassim, Firas
Braaf, Boy
Khoueir, Ziad
Poon, Linda Yi-Chieh
Ben-David, Geulah S.
Papadogeorgou, Georgia
Tsikata, Edem
Simavli, Huseyin
Que, Christian
Lee, Ramon
Shieh, Eric
Vakoc, Benjamin J.
Bouma, Brett E.
de Boer, Johannes F.
Chen, Teresa C.
Diagnostic Capability of 3D Peripapillary Retinal Volume for Glaucoma Using Optical Coherence Tomography Customized Software
title Diagnostic Capability of 3D Peripapillary Retinal Volume for Glaucoma Using Optical Coherence Tomography Customized Software
title_full Diagnostic Capability of 3D Peripapillary Retinal Volume for Glaucoma Using Optical Coherence Tomography Customized Software
title_fullStr Diagnostic Capability of 3D Peripapillary Retinal Volume for Glaucoma Using Optical Coherence Tomography Customized Software
title_full_unstemmed Diagnostic Capability of 3D Peripapillary Retinal Volume for Glaucoma Using Optical Coherence Tomography Customized Software
title_short Diagnostic Capability of 3D Peripapillary Retinal Volume for Glaucoma Using Optical Coherence Tomography Customized Software
title_sort diagnostic capability of 3d peripapillary retinal volume for glaucoma using optical coherence tomography customized software
topic Original Studies
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6727946/
https://www.ncbi.nlm.nih.gov/pubmed/31180936
http://dx.doi.org/10.1097/IJG.0000000000001291
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