Cargando…

Entomological assessment of dengue virus transmission risk in three urban areas of Kenya

Urbanization is one of the major drivers of dengue epidemics globally. In Kenya, an intriguing pattern of urban dengue virus epidemics has been documented in which recurrent epidemics are reported from the coastal city of Mombasa, whereas no outbreaks occur in the two major inland cities of Kisumu a...

Descripción completa

Detalles Bibliográficos
Autores principales: Agha, Sheila B., Tchouassi, David P., Turell, Michael J., Bastos, Armanda D. S., Sang, Rosemary
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6728053/
https://www.ncbi.nlm.nih.gov/pubmed/31442223
http://dx.doi.org/10.1371/journal.pntd.0007686
_version_ 1783449370137460736
author Agha, Sheila B.
Tchouassi, David P.
Turell, Michael J.
Bastos, Armanda D. S.
Sang, Rosemary
author_facet Agha, Sheila B.
Tchouassi, David P.
Turell, Michael J.
Bastos, Armanda D. S.
Sang, Rosemary
author_sort Agha, Sheila B.
collection PubMed
description Urbanization is one of the major drivers of dengue epidemics globally. In Kenya, an intriguing pattern of urban dengue virus epidemics has been documented in which recurrent epidemics are reported from the coastal city of Mombasa, whereas no outbreaks occur in the two major inland cities of Kisumu and Nairobi. In an attempt to understand the entomological risk factors underlying the observed urban dengue epidemic pattern in Kenya, we evaluated vector density, human feeding patterns, vector genetics, and prevailing environmental temperature to establish how these may interact with one another to shape the disease transmission pattern. We determined that (i) Nairobi and Kisumu had lower vector density and human blood indices, respectively, than Mombasa, (ii) vector competence for dengue-2 virus was comparable among Ae. aegypti populations from the three cities, with no discernible association between susceptibility and vector cytochrome c oxidase subunit 1 gene variation, and (iii) vector competence was temperature-dependent. Our study suggests that lower temperature and Ae. aegypti vector density in Nairobi may be responsible for the absence of dengue outbreaks in the capital city, whereas differences in feeding behavior, but not vector competence, temperature, or vector density, contribute in part to the observed recurrent dengue epidemics in coastal Mombasa compared to Kisumu.
format Online
Article
Text
id pubmed-6728053
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-67280532019-09-10 Entomological assessment of dengue virus transmission risk in three urban areas of Kenya Agha, Sheila B. Tchouassi, David P. Turell, Michael J. Bastos, Armanda D. S. Sang, Rosemary PLoS Negl Trop Dis Research Article Urbanization is one of the major drivers of dengue epidemics globally. In Kenya, an intriguing pattern of urban dengue virus epidemics has been documented in which recurrent epidemics are reported from the coastal city of Mombasa, whereas no outbreaks occur in the two major inland cities of Kisumu and Nairobi. In an attempt to understand the entomological risk factors underlying the observed urban dengue epidemic pattern in Kenya, we evaluated vector density, human feeding patterns, vector genetics, and prevailing environmental temperature to establish how these may interact with one another to shape the disease transmission pattern. We determined that (i) Nairobi and Kisumu had lower vector density and human blood indices, respectively, than Mombasa, (ii) vector competence for dengue-2 virus was comparable among Ae. aegypti populations from the three cities, with no discernible association between susceptibility and vector cytochrome c oxidase subunit 1 gene variation, and (iii) vector competence was temperature-dependent. Our study suggests that lower temperature and Ae. aegypti vector density in Nairobi may be responsible for the absence of dengue outbreaks in the capital city, whereas differences in feeding behavior, but not vector competence, temperature, or vector density, contribute in part to the observed recurrent dengue epidemics in coastal Mombasa compared to Kisumu. Public Library of Science 2019-08-23 /pmc/articles/PMC6728053/ /pubmed/31442223 http://dx.doi.org/10.1371/journal.pntd.0007686 Text en © 2019 Agha et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Agha, Sheila B.
Tchouassi, David P.
Turell, Michael J.
Bastos, Armanda D. S.
Sang, Rosemary
Entomological assessment of dengue virus transmission risk in three urban areas of Kenya
title Entomological assessment of dengue virus transmission risk in three urban areas of Kenya
title_full Entomological assessment of dengue virus transmission risk in three urban areas of Kenya
title_fullStr Entomological assessment of dengue virus transmission risk in three urban areas of Kenya
title_full_unstemmed Entomological assessment of dengue virus transmission risk in three urban areas of Kenya
title_short Entomological assessment of dengue virus transmission risk in three urban areas of Kenya
title_sort entomological assessment of dengue virus transmission risk in three urban areas of kenya
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6728053/
https://www.ncbi.nlm.nih.gov/pubmed/31442223
http://dx.doi.org/10.1371/journal.pntd.0007686
work_keys_str_mv AT aghasheilab entomologicalassessmentofdenguevirustransmissionriskinthreeurbanareasofkenya
AT tchouassidavidp entomologicalassessmentofdenguevirustransmissionriskinthreeurbanareasofkenya
AT turellmichaelj entomologicalassessmentofdenguevirustransmissionriskinthreeurbanareasofkenya
AT bastosarmandads entomologicalassessmentofdenguevirustransmissionriskinthreeurbanareasofkenya
AT sangrosemary entomologicalassessmentofdenguevirustransmissionriskinthreeurbanareasofkenya