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Entomological assessment of dengue virus transmission risk in three urban areas of Kenya
Urbanization is one of the major drivers of dengue epidemics globally. In Kenya, an intriguing pattern of urban dengue virus epidemics has been documented in which recurrent epidemics are reported from the coastal city of Mombasa, whereas no outbreaks occur in the two major inland cities of Kisumu a...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6728053/ https://www.ncbi.nlm.nih.gov/pubmed/31442223 http://dx.doi.org/10.1371/journal.pntd.0007686 |
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author | Agha, Sheila B. Tchouassi, David P. Turell, Michael J. Bastos, Armanda D. S. Sang, Rosemary |
author_facet | Agha, Sheila B. Tchouassi, David P. Turell, Michael J. Bastos, Armanda D. S. Sang, Rosemary |
author_sort | Agha, Sheila B. |
collection | PubMed |
description | Urbanization is one of the major drivers of dengue epidemics globally. In Kenya, an intriguing pattern of urban dengue virus epidemics has been documented in which recurrent epidemics are reported from the coastal city of Mombasa, whereas no outbreaks occur in the two major inland cities of Kisumu and Nairobi. In an attempt to understand the entomological risk factors underlying the observed urban dengue epidemic pattern in Kenya, we evaluated vector density, human feeding patterns, vector genetics, and prevailing environmental temperature to establish how these may interact with one another to shape the disease transmission pattern. We determined that (i) Nairobi and Kisumu had lower vector density and human blood indices, respectively, than Mombasa, (ii) vector competence for dengue-2 virus was comparable among Ae. aegypti populations from the three cities, with no discernible association between susceptibility and vector cytochrome c oxidase subunit 1 gene variation, and (iii) vector competence was temperature-dependent. Our study suggests that lower temperature and Ae. aegypti vector density in Nairobi may be responsible for the absence of dengue outbreaks in the capital city, whereas differences in feeding behavior, but not vector competence, temperature, or vector density, contribute in part to the observed recurrent dengue epidemics in coastal Mombasa compared to Kisumu. |
format | Online Article Text |
id | pubmed-6728053 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-67280532019-09-10 Entomological assessment of dengue virus transmission risk in three urban areas of Kenya Agha, Sheila B. Tchouassi, David P. Turell, Michael J. Bastos, Armanda D. S. Sang, Rosemary PLoS Negl Trop Dis Research Article Urbanization is one of the major drivers of dengue epidemics globally. In Kenya, an intriguing pattern of urban dengue virus epidemics has been documented in which recurrent epidemics are reported from the coastal city of Mombasa, whereas no outbreaks occur in the two major inland cities of Kisumu and Nairobi. In an attempt to understand the entomological risk factors underlying the observed urban dengue epidemic pattern in Kenya, we evaluated vector density, human feeding patterns, vector genetics, and prevailing environmental temperature to establish how these may interact with one another to shape the disease transmission pattern. We determined that (i) Nairobi and Kisumu had lower vector density and human blood indices, respectively, than Mombasa, (ii) vector competence for dengue-2 virus was comparable among Ae. aegypti populations from the three cities, with no discernible association between susceptibility and vector cytochrome c oxidase subunit 1 gene variation, and (iii) vector competence was temperature-dependent. Our study suggests that lower temperature and Ae. aegypti vector density in Nairobi may be responsible for the absence of dengue outbreaks in the capital city, whereas differences in feeding behavior, but not vector competence, temperature, or vector density, contribute in part to the observed recurrent dengue epidemics in coastal Mombasa compared to Kisumu. Public Library of Science 2019-08-23 /pmc/articles/PMC6728053/ /pubmed/31442223 http://dx.doi.org/10.1371/journal.pntd.0007686 Text en © 2019 Agha et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Agha, Sheila B. Tchouassi, David P. Turell, Michael J. Bastos, Armanda D. S. Sang, Rosemary Entomological assessment of dengue virus transmission risk in three urban areas of Kenya |
title | Entomological assessment of dengue virus transmission risk in three urban areas of Kenya |
title_full | Entomological assessment of dengue virus transmission risk in three urban areas of Kenya |
title_fullStr | Entomological assessment of dengue virus transmission risk in three urban areas of Kenya |
title_full_unstemmed | Entomological assessment of dengue virus transmission risk in three urban areas of Kenya |
title_short | Entomological assessment of dengue virus transmission risk in three urban areas of Kenya |
title_sort | entomological assessment of dengue virus transmission risk in three urban areas of kenya |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6728053/ https://www.ncbi.nlm.nih.gov/pubmed/31442223 http://dx.doi.org/10.1371/journal.pntd.0007686 |
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