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Quantitative mapping of protein-peptide affinity landscapes using spectrally encoded beads

Transient, regulated binding of globular protein domains to Short Linear Motifs (SLiMs) in disordered regions of other proteins drives cellular signaling. Mapping the energy landscapes of these interactions is essential for deciphering and perturbing signaling networks but is challenging due to thei...

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Detalles Bibliográficos
Autores principales:	Nguyen, Huy Quoc, Roy, Jagoree, Harink, Björn, Damle, Nikhil P, Latorraca, Naomi R, Baxter, Brian C, Brower, Kara, Longwell, Scott A, Kortemme, Tanja, Thorn, Kurt S, Cyert, Martha S, Fordyce, Polly Morrell
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2019
Materias:	Biochemistry and Chemical Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6728138/ https://www.ncbi.nlm.nih.gov/pubmed/31282865 http://dx.doi.org/10.7554/eLife.40499

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