Immuno-SABER enables highly multiplexed and amplified protein imaging in tissues

Spatial mapping of proteins in tissues is hindered by limitations in multiplexing, sensitivity, and throughput. Here we report immunostaining with signal amplification by exchange reaction (Immuno-SABER), which achieves highly multiplexed signal amplification via DNA-barcoded antibodies and orthogon...

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Detalles Bibliográficos
Autores principales: Saka, Sinem K., Wang, Yu, Kishi, Jocelyn Y., Zhu, Allen, Zeng, Yitian, Xie, Wenxin, Kirli, Koray, Yapp, Clarence, Cicconet, Marcelo, Beliveau, Brian J., Lapan, Sylvain W., Yin, Siyuan, Lin, Millicent, Boyden, Edward S., Kaeser, Pascal S., Pihan, German, Church, George M., Yin, Peng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6728175/
https://www.ncbi.nlm.nih.gov/pubmed/31427819
http://dx.doi.org/10.1038/s41587-019-0207-y

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