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High-throughput determination of the antigen specificities of T cell receptors in single cells

We present tetramer-associated T-cell receptor sequencing (TetTCR-Seq), a method to link T cell receptor (TCR) sequences to their cognate antigens in single cells at high throughput. Binding is determined using a library of DNA-barcoded antigen tetramers that is rapidly generated by in vitro transcr...

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Detalles Bibliográficos
Autores principales:	Zhang, Shu-Qi, Ma, Ke-Yue, Schonnesen, Alexandra A., Zhang, Mingliang, He, Chenfeng, Sun, Eric, Williams, Chad M., Jia, Weiping, Jiang, Ning
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6728224/ https://www.ncbi.nlm.nih.gov/pubmed/30418433 http://dx.doi.org/10.1038/nbt.4282

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