Multilevel structure–activity profiling reveals multiple green tea compound families that each modulate ubiquitin-activating enzyme and ubiquitination by a distinct mechanism

We developed and implemented a reconstituted system to screen for modulators of the ubiquitination of proliferating cell nuclear antigen, a process that activates pathways of DNA damage tolerance and drug resistance. We identified the primary putatively health-beneficial green tea polyphenol epigall...

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Detalles Bibliográficos
Autores principales: Fenteany, Gabriel, Gaur, Paras, Hegedűs, Lili, Dudás, Kata, Kiss, Ernő, Wéber, Edit, Hackler, László, Martinek, Tamás, Puskás, László G., Haracska, Lajos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6728334/
https://www.ncbi.nlm.nih.gov/pubmed/31488855
http://dx.doi.org/10.1038/s41598-019-48888-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6728334/
https://www.ncbi.nlm.nih.gov/pubmed/31488855
http://dx.doi.org/10.1038/s41598-019-48888-6

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