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Hippocampal-neocortical interactions sharpen over time for predictive actions

When an action is familiar, we are able to anticipate how it will change the state of the world. These expectations can result from retrieval of action-outcome associations in the hippocampus and the reinstatement of anticipated outcomes in visual cortex. How does this role for the hippocampus in ac...

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Autores principales: Hindy, Nicholas C., Avery, Emily W., Turk-Browne, Nicholas B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6728336/
https://www.ncbi.nlm.nih.gov/pubmed/31488845
http://dx.doi.org/10.1038/s41467-019-12016-9
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author Hindy, Nicholas C.
Avery, Emily W.
Turk-Browne, Nicholas B.
author_facet Hindy, Nicholas C.
Avery, Emily W.
Turk-Browne, Nicholas B.
author_sort Hindy, Nicholas C.
collection PubMed
description When an action is familiar, we are able to anticipate how it will change the state of the world. These expectations can result from retrieval of action-outcome associations in the hippocampus and the reinstatement of anticipated outcomes in visual cortex. How does this role for the hippocampus in action-based prediction change over time? We use high-resolution fMRI and a dual-training behavioral paradigm to examine how the hippocampus interacts with visual cortex during predictive and nonpredictive actions learned either three days earlier or immediately before the scan. Just-learned associations led to comparable background connectivity between the hippocampus and V1/V2, regardless of whether actions predicted outcomes. However, three-day-old associations led to stronger background connectivity and greater differentiation between neural patterns for predictive vs. nonpredictive actions. Hippocampal prediction may initially reflect indiscriminate binding of co-occurring events, with action information pruning weaker associations and leading to more selective and accurate predictions over time.
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spelling pubmed-67283362019-09-09 Hippocampal-neocortical interactions sharpen over time for predictive actions Hindy, Nicholas C. Avery, Emily W. Turk-Browne, Nicholas B. Nat Commun Article When an action is familiar, we are able to anticipate how it will change the state of the world. These expectations can result from retrieval of action-outcome associations in the hippocampus and the reinstatement of anticipated outcomes in visual cortex. How does this role for the hippocampus in action-based prediction change over time? We use high-resolution fMRI and a dual-training behavioral paradigm to examine how the hippocampus interacts with visual cortex during predictive and nonpredictive actions learned either three days earlier or immediately before the scan. Just-learned associations led to comparable background connectivity between the hippocampus and V1/V2, regardless of whether actions predicted outcomes. However, three-day-old associations led to stronger background connectivity and greater differentiation between neural patterns for predictive vs. nonpredictive actions. Hippocampal prediction may initially reflect indiscriminate binding of co-occurring events, with action information pruning weaker associations and leading to more selective and accurate predictions over time. Nature Publishing Group UK 2019-09-05 /pmc/articles/PMC6728336/ /pubmed/31488845 http://dx.doi.org/10.1038/s41467-019-12016-9 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Hindy, Nicholas C.
Avery, Emily W.
Turk-Browne, Nicholas B.
Hippocampal-neocortical interactions sharpen over time for predictive actions
title Hippocampal-neocortical interactions sharpen over time for predictive actions
title_full Hippocampal-neocortical interactions sharpen over time for predictive actions
title_fullStr Hippocampal-neocortical interactions sharpen over time for predictive actions
title_full_unstemmed Hippocampal-neocortical interactions sharpen over time for predictive actions
title_short Hippocampal-neocortical interactions sharpen over time for predictive actions
title_sort hippocampal-neocortical interactions sharpen over time for predictive actions
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6728336/
https://www.ncbi.nlm.nih.gov/pubmed/31488845
http://dx.doi.org/10.1038/s41467-019-12016-9
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