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Neural sensitization improves encoding fidelity in the primate retina
An animal’s motion through the environment can induce large and frequent fluctuations in light intensity on the retina. These fluctuations pose a major challenge to neural circuits tasked with encoding visual information, as they can cause cells to adapt and lose sensitivity. Here, we report that se...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6728337/ https://www.ncbi.nlm.nih.gov/pubmed/31488831 http://dx.doi.org/10.1038/s41467-019-11734-4 |
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author | Appleby, Todd R. Manookin, Michael B. |
author_facet | Appleby, Todd R. Manookin, Michael B. |
author_sort | Appleby, Todd R. |
collection | PubMed |
description | An animal’s motion through the environment can induce large and frequent fluctuations in light intensity on the retina. These fluctuations pose a major challenge to neural circuits tasked with encoding visual information, as they can cause cells to adapt and lose sensitivity. Here, we report that sensitization, a short-term plasticity mechanism, solves this difficult computational problem by maintaining neuronal sensitivity in the face of these fluctuations. The numerically dominant output pathway in the macaque monkey retina, the midget (parvocellular-projecting) pathway, undergoes sensitization under specific conditions, including simulated eye movements. Sensitization is present in the excitatory synaptic inputs from midget bipolar cells and is mediated by presynaptic disinhibition from a wide-field mechanism extending >0.5 mm along the retinal surface. Direct physiological recordings and a computational model indicate that sensitization in the midget pathway supports accurate sensory encoding and prevents a loss of responsiveness during dynamic visual processing. |
format | Online Article Text |
id | pubmed-6728337 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-67283372019-09-09 Neural sensitization improves encoding fidelity in the primate retina Appleby, Todd R. Manookin, Michael B. Nat Commun Article An animal’s motion through the environment can induce large and frequent fluctuations in light intensity on the retina. These fluctuations pose a major challenge to neural circuits tasked with encoding visual information, as they can cause cells to adapt and lose sensitivity. Here, we report that sensitization, a short-term plasticity mechanism, solves this difficult computational problem by maintaining neuronal sensitivity in the face of these fluctuations. The numerically dominant output pathway in the macaque monkey retina, the midget (parvocellular-projecting) pathway, undergoes sensitization under specific conditions, including simulated eye movements. Sensitization is present in the excitatory synaptic inputs from midget bipolar cells and is mediated by presynaptic disinhibition from a wide-field mechanism extending >0.5 mm along the retinal surface. Direct physiological recordings and a computational model indicate that sensitization in the midget pathway supports accurate sensory encoding and prevents a loss of responsiveness during dynamic visual processing. Nature Publishing Group UK 2019-09-05 /pmc/articles/PMC6728337/ /pubmed/31488831 http://dx.doi.org/10.1038/s41467-019-11734-4 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Appleby, Todd R. Manookin, Michael B. Neural sensitization improves encoding fidelity in the primate retina |
title | Neural sensitization improves encoding fidelity in the primate retina |
title_full | Neural sensitization improves encoding fidelity in the primate retina |
title_fullStr | Neural sensitization improves encoding fidelity in the primate retina |
title_full_unstemmed | Neural sensitization improves encoding fidelity in the primate retina |
title_short | Neural sensitization improves encoding fidelity in the primate retina |
title_sort | neural sensitization improves encoding fidelity in the primate retina |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6728337/ https://www.ncbi.nlm.nih.gov/pubmed/31488831 http://dx.doi.org/10.1038/s41467-019-11734-4 |
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