Zika virus replicates in adult human brain tissue and impairs synapses and memory in mice

Neurological complications affecting the central nervous system have been reported in adult patients infected by Zika virus (ZIKV) but the underlying mechanisms remain unknown. Here, we report that ZIKV replicates in human and mouse adult brain tissue, targeting mature neurons. ZIKV preferentially t...

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Detalles Bibliográficos
Autores principales: Figueiredo, Claudia P., Barros-Aragão, Fernanda G. Q., Neris, Rômulo L. S., Frost, Paula S., Soares, Carolina, Souza, Isis N. O., Zeidler, Julianna D., Zamberlan, Daniele C., de Sousa, Virginia L., Souza, Amanda S., Guimarães, André Luis A., Bellio, Maria, Marcondes de Souza, Jorge, Alves-Leon, Soniza V., Neves, Gilda A., Paula-Neto, Heitor A., Castro, Newton G., De Felice, Fernanda G., Assunção-Miranda, Iranaia, Clarke, Julia R., Da Poian, Andrea T., Ferreira, Sergio T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6728367/
https://www.ncbi.nlm.nih.gov/pubmed/31488835
http://dx.doi.org/10.1038/s41467-019-11866-7

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