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Comparable Rates of Integrated Myofibrillar Protein Synthesis Between Endurance-Trained Master Athletes and Untrained Older Individuals

BACKGROUND: An impaired muscle anabolic response to exercise and protein nutrition is thought to underpin age-related muscle loss, which may be exacerbated by aspects of biological aging that may not be present in older individuals who have undertaken long-term high-level exercise training, or maste...

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Autores principales: McKendry, James, Shad, Brandon J., Smeuninx, Benoit, Oikawa, Sara Y., Wallis, Gareth, Greig, Carolyn, Phillips, Stuart M., Breen, Leigh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6728413/
https://www.ncbi.nlm.nih.gov/pubmed/31543824
http://dx.doi.org/10.3389/fphys.2019.01084
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author McKendry, James
Shad, Brandon J.
Smeuninx, Benoit
Oikawa, Sara Y.
Wallis, Gareth
Greig, Carolyn
Phillips, Stuart M.
Breen, Leigh
author_facet McKendry, James
Shad, Brandon J.
Smeuninx, Benoit
Oikawa, Sara Y.
Wallis, Gareth
Greig, Carolyn
Phillips, Stuart M.
Breen, Leigh
author_sort McKendry, James
collection PubMed
description BACKGROUND: An impaired muscle anabolic response to exercise and protein nutrition is thought to underpin age-related muscle loss, which may be exacerbated by aspects of biological aging that may not be present in older individuals who have undertaken long-term high-level exercise training, or master athletes (MA). The aim of this study was to compare rested-state and exercise-induced rates of integrated myofibrillar protein synthesis (iMyoPS) and intracellular signaling in endurance trained MA and healthy age-matched untrained individuals (Older Controls). METHODS: In a parallel study design, iMyoPS rates were determined over 48 h in the rested-state and following a bout of unaccustomed resistance exercise (RE) in OC (n = 8 males; 73.5 ± 3.3 years) and endurance-trained MA (n = 7 males; 68.9 ± 5.7 years). Intramuscular anabolic signaling was also determined. During the iMyoPS measurement period, physical activity was monitored via accelerometry and dietary intake was controlled. RESULTS: Anthropometrics, habitual activity, and dietary intake were similar between groups. There was no difference in rested-state rates of iMyoPS between OC (1.47 ± 0.06%⋅day(–1)) and MA (1.46 ± 0.08%⋅day(–1)). RE significantly increased iMyoPS above rest in both OC (1.60 ± 0.08%⋅day(–1), P < 0.01) and MA (1.61 ± 0.08%⋅day(–1), P < 0.01), with no difference between groups. Akt(Thr308) phosphorylation increased at 1 h post-RE in OC (P < 0.05), but not MA. No other between-group differences in intramuscular signaling were apparent at any time-point. CONCLUSION: While our sample size is limited, these data suggest that rested-state and RE-induced iMyoPS are indistinguishable between MA and OC. Importantly, the OC retain a capacity for RE-induced stimulation of skeletal muscle remodeling.
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spelling pubmed-67284132019-09-20 Comparable Rates of Integrated Myofibrillar Protein Synthesis Between Endurance-Trained Master Athletes and Untrained Older Individuals McKendry, James Shad, Brandon J. Smeuninx, Benoit Oikawa, Sara Y. Wallis, Gareth Greig, Carolyn Phillips, Stuart M. Breen, Leigh Front Physiol Physiology BACKGROUND: An impaired muscle anabolic response to exercise and protein nutrition is thought to underpin age-related muscle loss, which may be exacerbated by aspects of biological aging that may not be present in older individuals who have undertaken long-term high-level exercise training, or master athletes (MA). The aim of this study was to compare rested-state and exercise-induced rates of integrated myofibrillar protein synthesis (iMyoPS) and intracellular signaling in endurance trained MA and healthy age-matched untrained individuals (Older Controls). METHODS: In a parallel study design, iMyoPS rates were determined over 48 h in the rested-state and following a bout of unaccustomed resistance exercise (RE) in OC (n = 8 males; 73.5 ± 3.3 years) and endurance-trained MA (n = 7 males; 68.9 ± 5.7 years). Intramuscular anabolic signaling was also determined. During the iMyoPS measurement period, physical activity was monitored via accelerometry and dietary intake was controlled. RESULTS: Anthropometrics, habitual activity, and dietary intake were similar between groups. There was no difference in rested-state rates of iMyoPS between OC (1.47 ± 0.06%⋅day(–1)) and MA (1.46 ± 0.08%⋅day(–1)). RE significantly increased iMyoPS above rest in both OC (1.60 ± 0.08%⋅day(–1), P < 0.01) and MA (1.61 ± 0.08%⋅day(–1), P < 0.01), with no difference between groups. Akt(Thr308) phosphorylation increased at 1 h post-RE in OC (P < 0.05), but not MA. No other between-group differences in intramuscular signaling were apparent at any time-point. CONCLUSION: While our sample size is limited, these data suggest that rested-state and RE-induced iMyoPS are indistinguishable between MA and OC. Importantly, the OC retain a capacity for RE-induced stimulation of skeletal muscle remodeling. Frontiers Media S.A. 2019-08-30 /pmc/articles/PMC6728413/ /pubmed/31543824 http://dx.doi.org/10.3389/fphys.2019.01084 Text en Copyright © 2019 McKendry, Shad, Smeuninx, Oikawa, Wallis, Greig, Phillips and Breen. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
McKendry, James
Shad, Brandon J.
Smeuninx, Benoit
Oikawa, Sara Y.
Wallis, Gareth
Greig, Carolyn
Phillips, Stuart M.
Breen, Leigh
Comparable Rates of Integrated Myofibrillar Protein Synthesis Between Endurance-Trained Master Athletes and Untrained Older Individuals
title Comparable Rates of Integrated Myofibrillar Protein Synthesis Between Endurance-Trained Master Athletes and Untrained Older Individuals
title_full Comparable Rates of Integrated Myofibrillar Protein Synthesis Between Endurance-Trained Master Athletes and Untrained Older Individuals
title_fullStr Comparable Rates of Integrated Myofibrillar Protein Synthesis Between Endurance-Trained Master Athletes and Untrained Older Individuals
title_full_unstemmed Comparable Rates of Integrated Myofibrillar Protein Synthesis Between Endurance-Trained Master Athletes and Untrained Older Individuals
title_short Comparable Rates of Integrated Myofibrillar Protein Synthesis Between Endurance-Trained Master Athletes and Untrained Older Individuals
title_sort comparable rates of integrated myofibrillar protein synthesis between endurance-trained master athletes and untrained older individuals
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6728413/
https://www.ncbi.nlm.nih.gov/pubmed/31543824
http://dx.doi.org/10.3389/fphys.2019.01084
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