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Serum Potassium, Sodium, and Chloride Levels in Sickle Cell Disease Patients and Healthy Controls: A Case-Control Study at Korle-Bu Teaching Hospital, Accra

The activity of Na(+)-K(+) ATPase is altered in sickle cell disease (SCD), which affects serum electrolyte levels. This alteration is associated with several complications in sickle cell patients. This study evaluated the serum levels of sodium, potassium, and chloride in patients with SCD. The stud...

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Autores principales: Antwi-Boasiako, Charles, Kusi-Mensah, Yaw A, Hayfron-Benjamin, Charles, Aryee, Robert, Dankwah, Gifty Boatemaah, Abla, Kwawukume Lim, Owusu Darkwa, Ebenezer, Botchway, Felix Abekah, Sampene-Donkor, Eric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6728659/
https://www.ncbi.nlm.nih.gov/pubmed/31523130
http://dx.doi.org/10.1177/1177271919873889
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author Antwi-Boasiako, Charles
Kusi-Mensah, Yaw A
Hayfron-Benjamin, Charles
Aryee, Robert
Dankwah, Gifty Boatemaah
Abla, Kwawukume Lim
Owusu Darkwa, Ebenezer
Botchway, Felix Abekah
Sampene-Donkor, Eric
author_facet Antwi-Boasiako, Charles
Kusi-Mensah, Yaw A
Hayfron-Benjamin, Charles
Aryee, Robert
Dankwah, Gifty Boatemaah
Abla, Kwawukume Lim
Owusu Darkwa, Ebenezer
Botchway, Felix Abekah
Sampene-Donkor, Eric
author_sort Antwi-Boasiako, Charles
collection PubMed
description The activity of Na(+)-K(+) ATPase is altered in sickle cell disease (SCD), which affects serum electrolyte levels. This alteration is associated with several complications in sickle cell patients. This study evaluated the serum levels of sodium, potassium, and chloride in patients with SCD. The study was a case-control cross-sectional study involving 120 SCD patients in the steady state and 48 ‘healthy’ controls. The SCD patients were made up of 69 HbSS patients and 41 HbSC patients. Serum electrolyte levels (Na(+), K(+), and Cl(−)) were measured using a Flame Atomic Absorption Spectrometer (Variant 240FS; Varian Australia Pty Ltd). Serum sodium levels were significantly lower in the sickle cell patients, compared with their ‘healthy’ counterparts (P = .0001). Although the study found significantly higher serum levels of potassium in the SCD patients (P = .0001), there was no significant difference in serum chloride levels between patients with SCD and the controls (P = .098). Serum sodium and chloride levels were not significantly different in both HbSS and HbSC patients (P = .197 and P = .553, respectively). The level of serum potassium in the HbSS patients was, however, significantly higher compared with those with the HbSC genotype (P = .0001). There is higher efflux of K(+) from the intracellular into the extracellular space in HbSS patients, which may lead to red cell membrane dysfunction and associated complications.
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spelling pubmed-67286592019-09-13 Serum Potassium, Sodium, and Chloride Levels in Sickle Cell Disease Patients and Healthy Controls: A Case-Control Study at Korle-Bu Teaching Hospital, Accra Antwi-Boasiako, Charles Kusi-Mensah, Yaw A Hayfron-Benjamin, Charles Aryee, Robert Dankwah, Gifty Boatemaah Abla, Kwawukume Lim Owusu Darkwa, Ebenezer Botchway, Felix Abekah Sampene-Donkor, Eric Biomark Insights Original Research The activity of Na(+)-K(+) ATPase is altered in sickle cell disease (SCD), which affects serum electrolyte levels. This alteration is associated with several complications in sickle cell patients. This study evaluated the serum levels of sodium, potassium, and chloride in patients with SCD. The study was a case-control cross-sectional study involving 120 SCD patients in the steady state and 48 ‘healthy’ controls. The SCD patients were made up of 69 HbSS patients and 41 HbSC patients. Serum electrolyte levels (Na(+), K(+), and Cl(−)) were measured using a Flame Atomic Absorption Spectrometer (Variant 240FS; Varian Australia Pty Ltd). Serum sodium levels were significantly lower in the sickle cell patients, compared with their ‘healthy’ counterparts (P = .0001). Although the study found significantly higher serum levels of potassium in the SCD patients (P = .0001), there was no significant difference in serum chloride levels between patients with SCD and the controls (P = .098). Serum sodium and chloride levels were not significantly different in both HbSS and HbSC patients (P = .197 and P = .553, respectively). The level of serum potassium in the HbSS patients was, however, significantly higher compared with those with the HbSC genotype (P = .0001). There is higher efflux of K(+) from the intracellular into the extracellular space in HbSS patients, which may lead to red cell membrane dysfunction and associated complications. SAGE Publications 2019-09-05 /pmc/articles/PMC6728659/ /pubmed/31523130 http://dx.doi.org/10.1177/1177271919873889 Text en © The Author(s) 2019 http://www.creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Original Research
Antwi-Boasiako, Charles
Kusi-Mensah, Yaw A
Hayfron-Benjamin, Charles
Aryee, Robert
Dankwah, Gifty Boatemaah
Abla, Kwawukume Lim
Owusu Darkwa, Ebenezer
Botchway, Felix Abekah
Sampene-Donkor, Eric
Serum Potassium, Sodium, and Chloride Levels in Sickle Cell Disease Patients and Healthy Controls: A Case-Control Study at Korle-Bu Teaching Hospital, Accra
title Serum Potassium, Sodium, and Chloride Levels in Sickle Cell Disease Patients and Healthy Controls: A Case-Control Study at Korle-Bu Teaching Hospital, Accra
title_full Serum Potassium, Sodium, and Chloride Levels in Sickle Cell Disease Patients and Healthy Controls: A Case-Control Study at Korle-Bu Teaching Hospital, Accra
title_fullStr Serum Potassium, Sodium, and Chloride Levels in Sickle Cell Disease Patients and Healthy Controls: A Case-Control Study at Korle-Bu Teaching Hospital, Accra
title_full_unstemmed Serum Potassium, Sodium, and Chloride Levels in Sickle Cell Disease Patients and Healthy Controls: A Case-Control Study at Korle-Bu Teaching Hospital, Accra
title_short Serum Potassium, Sodium, and Chloride Levels in Sickle Cell Disease Patients and Healthy Controls: A Case-Control Study at Korle-Bu Teaching Hospital, Accra
title_sort serum potassium, sodium, and chloride levels in sickle cell disease patients and healthy controls: a case-control study at korle-bu teaching hospital, accra
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6728659/
https://www.ncbi.nlm.nih.gov/pubmed/31523130
http://dx.doi.org/10.1177/1177271919873889
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