The Targeted Therapies Era Beyond the Surgical Point of View: What Spine Surgeons Should Know Before Approaching Spinal Metastases

In the last few years, the treatment of spinal metastases has significantly changed. This is due to the advancements in surgical technique, radiotherapy, and chemotherapy which have enriched the multidisciplinary management. Above all, the field of molecular biology of tumors is in continuous and pr...

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Autores principales: Cofano, Fabio, Monticelli, Matteo, Ajello, Marco, Zenga, Francesco, Marengo, Nicola, Di Perna, Giuseppe, Altieri, Roberto, Cassoni, Paola, Bertero, Luca, Melcarne, Antonio, Tartara, Fulvio, Ducati, Alessandro, Garbossa, Diego
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6728684/
https://www.ncbi.nlm.nih.gov/pubmed/31865766
http://dx.doi.org/10.1177/1073274819870549
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author Cofano, Fabio
Monticelli, Matteo
Ajello, Marco
Zenga, Francesco
Marengo, Nicola
Di Perna, Giuseppe
Altieri, Roberto
Cassoni, Paola
Bertero, Luca
Melcarne, Antonio
Tartara, Fulvio
Ducati, Alessandro
Garbossa, Diego
author_facet Cofano, Fabio
Monticelli, Matteo
Ajello, Marco
Zenga, Francesco
Marengo, Nicola
Di Perna, Giuseppe
Altieri, Roberto
Cassoni, Paola
Bertero, Luca
Melcarne, Antonio
Tartara, Fulvio
Ducati, Alessandro
Garbossa, Diego
author_sort Cofano, Fabio
collection PubMed
description In the last few years, the treatment of spinal metastases has significantly changed. This is due to the advancements in surgical technique, radiotherapy, and chemotherapy which have enriched the multidisciplinary management. Above all, the field of molecular biology of tumors is in continuous and prosperous evolution. In this review, the molecular markers and new approaches that have radically modified the chemotherapeutic strategy of the most common metastatic neoplasms will be examined together with clinical and surgical implications. The experience and skills of several different medical professionals are mandatory: an interdisciplinary oncology team represents the winning strategy in the treatment of patients with spinal metastases
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spelling pubmed-67286842019-09-13 The Targeted Therapies Era Beyond the Surgical Point of View: What Spine Surgeons Should Know Before Approaching Spinal Metastases Cofano, Fabio Monticelli, Matteo Ajello, Marco Zenga, Francesco Marengo, Nicola Di Perna, Giuseppe Altieri, Roberto Cassoni, Paola Bertero, Luca Melcarne, Antonio Tartara, Fulvio Ducati, Alessandro Garbossa, Diego Cancer Control Review In the last few years, the treatment of spinal metastases has significantly changed. This is due to the advancements in surgical technique, radiotherapy, and chemotherapy which have enriched the multidisciplinary management. Above all, the field of molecular biology of tumors is in continuous and prosperous evolution. In this review, the molecular markers and new approaches that have radically modified the chemotherapeutic strategy of the most common metastatic neoplasms will be examined together with clinical and surgical implications. The experience and skills of several different medical professionals are mandatory: an interdisciplinary oncology team represents the winning strategy in the treatment of patients with spinal metastases SAGE Publications 2019-09-04 /pmc/articles/PMC6728684/ /pubmed/31865766 http://dx.doi.org/10.1177/1073274819870549 Text en © The Author(s) 2019 http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Review
Cofano, Fabio
Monticelli, Matteo
Ajello, Marco
Zenga, Francesco
Marengo, Nicola
Di Perna, Giuseppe
Altieri, Roberto
Cassoni, Paola
Bertero, Luca
Melcarne, Antonio
Tartara, Fulvio
Ducati, Alessandro
Garbossa, Diego
The Targeted Therapies Era Beyond the Surgical Point of View: What Spine Surgeons Should Know Before Approaching Spinal Metastases
title The Targeted Therapies Era Beyond the Surgical Point of View: What Spine Surgeons Should Know Before Approaching Spinal Metastases
title_full The Targeted Therapies Era Beyond the Surgical Point of View: What Spine Surgeons Should Know Before Approaching Spinal Metastases
title_fullStr The Targeted Therapies Era Beyond the Surgical Point of View: What Spine Surgeons Should Know Before Approaching Spinal Metastases
title_full_unstemmed The Targeted Therapies Era Beyond the Surgical Point of View: What Spine Surgeons Should Know Before Approaching Spinal Metastases
title_short The Targeted Therapies Era Beyond the Surgical Point of View: What Spine Surgeons Should Know Before Approaching Spinal Metastases
title_sort targeted therapies era beyond the surgical point of view: what spine surgeons should know before approaching spinal metastases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6728684/
https://www.ncbi.nlm.nih.gov/pubmed/31865766
http://dx.doi.org/10.1177/1073274819870549
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