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Roux-en-Y gastric bypass enhances insulin secretion in type 2 diabetes via FXR-mediated TRPA1 expression

OBJECTIVE: Roux-en-Y gastric bypass surgery (RYGB) improves the first phase of glucose-stimulated insulin secretion (GSIS) in patients with type 2 diabetes. How it does so remains unclear. Farnesoid X receptor (FXR), the nuclear receptor of bile acids (BAs), is implicated in bariatric surgery. Moreo...

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Detalles Bibliográficos
Autores principales:	Kong, Xiangchen, Tu, Yifan, Li, Bingfeng, Zhang, Longmei, Feng, Linxian, Wang, Lixiang, Zhang, Lin, Zhou, Huarong, Hua, Xianxin, Ma, Xiaosong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2019
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6728758/ https://www.ncbi.nlm.nih.gov/pubmed/31668381 http://dx.doi.org/10.1016/j.molmet.2019.08.009

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