Effect of piceatannol-rich passion fruit seed extract on human glyoxalase I–mediated cancer cell growth

Passion fruit seed extract (PFSE), a product rich in stilbenes such as piceatannol and scirpusin B, has various physiological effects. It is unclear whether PFSE and its stilbene derivatives inhibit cancer cell proliferation via human glyoxalase I (GLO I), the rate-limiting enzyme for detoxification...

Descripción completa

Detalles Bibliográficos
Autores principales: Yamamoto, Takayuki, Sato, Akira, Takai, Yusuke, Yoshimori, Atsushi, Umehara, Masahiro, Ogino, Yoko, Inada, Mana, Shimada, Nami, Nishida, Aya, Ichida, Risa, Takasawa, Ryoko, Maruki-Uchida, Hiroko, Mori, Sadao, Sai, Masahiko, Morita, Minoru, Tanuma, Sei-ichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6728800/
https://www.ncbi.nlm.nih.gov/pubmed/31517069
http://dx.doi.org/10.1016/j.bbrep.2019.100684
Descripción
Sumario:Passion fruit seed extract (PFSE), a product rich in stilbenes such as piceatannol and scirpusin B, has various physiological effects. It is unclear whether PFSE and its stilbene derivatives inhibit cancer cell proliferation via human glyoxalase I (GLO I), the rate-limiting enzyme for detoxification of methylglyoxal. We examined the anticancer effects of PFSE in two types of human cancer cell lines with different GLO I expression levels, NCI–H522 cells (highly-expressed GLO I) and HCT116 cells (lowly-expressed GLO I). PFSE and its stilbenes inhibited GLO I activity. In addition, PFSE and its stilbenes supressed the cancer cell proliferation of NCI–H522 cells more than HCT116 cells. These observations suggest that PFSE can provide a novel anticancer strategy for prevention and treatment.

Ejemplares similares