Effect of piceatannol-rich passion fruit seed extract on human glyoxalase I–mediated cancer cell growth

Passion fruit seed extract (PFSE), a product rich in stilbenes such as piceatannol and scirpusin B, has various physiological effects. It is unclear whether PFSE and its stilbene derivatives inhibit cancer cell proliferation via human glyoxalase I (GLO I), the rate-limiting enzyme for detoxification...

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Autores principales: Yamamoto, Takayuki, Sato, Akira, Takai, Yusuke, Yoshimori, Atsushi, Umehara, Masahiro, Ogino, Yoko, Inada, Mana, Shimada, Nami, Nishida, Aya, Ichida, Risa, Takasawa, Ryoko, Maruki-Uchida, Hiroko, Mori, Sadao, Sai, Masahiko, Morita, Minoru, Tanuma, Sei-ichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6728800/
https://www.ncbi.nlm.nih.gov/pubmed/31517069
http://dx.doi.org/10.1016/j.bbrep.2019.100684
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author Yamamoto, Takayuki
Sato, Akira
Takai, Yusuke
Yoshimori, Atsushi
Umehara, Masahiro
Ogino, Yoko
Inada, Mana
Shimada, Nami
Nishida, Aya
Ichida, Risa
Takasawa, Ryoko
Maruki-Uchida, Hiroko
Mori, Sadao
Sai, Masahiko
Morita, Minoru
Tanuma, Sei-ichi
author_facet Yamamoto, Takayuki
Sato, Akira
Takai, Yusuke
Yoshimori, Atsushi
Umehara, Masahiro
Ogino, Yoko
Inada, Mana
Shimada, Nami
Nishida, Aya
Ichida, Risa
Takasawa, Ryoko
Maruki-Uchida, Hiroko
Mori, Sadao
Sai, Masahiko
Morita, Minoru
Tanuma, Sei-ichi
author_sort Yamamoto, Takayuki
collection PubMed
description Passion fruit seed extract (PFSE), a product rich in stilbenes such as piceatannol and scirpusin B, has various physiological effects. It is unclear whether PFSE and its stilbene derivatives inhibit cancer cell proliferation via human glyoxalase I (GLO I), the rate-limiting enzyme for detoxification of methylglyoxal. We examined the anticancer effects of PFSE in two types of human cancer cell lines with different GLO I expression levels, NCI–H522 cells (highly-expressed GLO I) and HCT116 cells (lowly-expressed GLO I). PFSE and its stilbenes inhibited GLO I activity. In addition, PFSE and its stilbenes supressed the cancer cell proliferation of NCI–H522 cells more than HCT116 cells. These observations suggest that PFSE can provide a novel anticancer strategy for prevention and treatment.
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spelling pubmed-67288002019-09-12 Effect of piceatannol-rich passion fruit seed extract on human glyoxalase I–mediated cancer cell growth Yamamoto, Takayuki Sato, Akira Takai, Yusuke Yoshimori, Atsushi Umehara, Masahiro Ogino, Yoko Inada, Mana Shimada, Nami Nishida, Aya Ichida, Risa Takasawa, Ryoko Maruki-Uchida, Hiroko Mori, Sadao Sai, Masahiko Morita, Minoru Tanuma, Sei-ichi Biochem Biophys Rep Research Article Passion fruit seed extract (PFSE), a product rich in stilbenes such as piceatannol and scirpusin B, has various physiological effects. It is unclear whether PFSE and its stilbene derivatives inhibit cancer cell proliferation via human glyoxalase I (GLO I), the rate-limiting enzyme for detoxification of methylglyoxal. We examined the anticancer effects of PFSE in two types of human cancer cell lines with different GLO I expression levels, NCI–H522 cells (highly-expressed GLO I) and HCT116 cells (lowly-expressed GLO I). PFSE and its stilbenes inhibited GLO I activity. In addition, PFSE and its stilbenes supressed the cancer cell proliferation of NCI–H522 cells more than HCT116 cells. These observations suggest that PFSE can provide a novel anticancer strategy for prevention and treatment. Elsevier 2019-08-30 /pmc/articles/PMC6728800/ /pubmed/31517069 http://dx.doi.org/10.1016/j.bbrep.2019.100684 Text en © 2019 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Research Article
Yamamoto, Takayuki
Sato, Akira
Takai, Yusuke
Yoshimori, Atsushi
Umehara, Masahiro
Ogino, Yoko
Inada, Mana
Shimada, Nami
Nishida, Aya
Ichida, Risa
Takasawa, Ryoko
Maruki-Uchida, Hiroko
Mori, Sadao
Sai, Masahiko
Morita, Minoru
Tanuma, Sei-ichi
Effect of piceatannol-rich passion fruit seed extract on human glyoxalase I–mediated cancer cell growth
title Effect of piceatannol-rich passion fruit seed extract on human glyoxalase I–mediated cancer cell growth
title_full Effect of piceatannol-rich passion fruit seed extract on human glyoxalase I–mediated cancer cell growth
title_fullStr Effect of piceatannol-rich passion fruit seed extract on human glyoxalase I–mediated cancer cell growth
title_full_unstemmed Effect of piceatannol-rich passion fruit seed extract on human glyoxalase I–mediated cancer cell growth
title_short Effect of piceatannol-rich passion fruit seed extract on human glyoxalase I–mediated cancer cell growth
title_sort effect of piceatannol-rich passion fruit seed extract on human glyoxalase i–mediated cancer cell growth
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6728800/
https://www.ncbi.nlm.nih.gov/pubmed/31517069
http://dx.doi.org/10.1016/j.bbrep.2019.100684
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