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Sexual trauma history is associated with reduced orbitofrontal network strength in substance-dependent women

AIM: Substance use disorders (SUDs) are highly comorbid with post-traumatic stress disorder (PTSD). PTSD-SUD comorbidity is associated with greater functional impairments and relapse risk. Women with SUDs experience markedly higher rates of trauma and PTSD compared to men with SUDs, particularly due...

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Autores principales: Poppa, Tasha, Droutman, Vita, Amaro, Hortensia, Black, David, Arnaudova, Inna, Monterosso, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6728879/
https://www.ncbi.nlm.nih.gov/pubmed/31472330
http://dx.doi.org/10.1016/j.nicl.2019.101973
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author Poppa, Tasha
Droutman, Vita
Amaro, Hortensia
Black, David
Arnaudova, Inna
Monterosso, John
author_facet Poppa, Tasha
Droutman, Vita
Amaro, Hortensia
Black, David
Arnaudova, Inna
Monterosso, John
author_sort Poppa, Tasha
collection PubMed
description AIM: Substance use disorders (SUDs) are highly comorbid with post-traumatic stress disorder (PTSD). PTSD-SUD comorbidity is associated with greater functional impairments and relapse risk. Women with SUDs experience markedly higher rates of trauma and PTSD compared to men with SUDs, particularly due to sexual and domestic abuse. Despite the strong association between trauma exposure and SUDs, the neurobiological correlates are understudied, particularly among females with SUDs. However, there is indication of abnormal somatic and interoceptive processing in women with PTSD. The present study examines interoception-linked differences in intrinsic brain networks in a group of women with SUDs and varying histories of trauma exposure, some of whom have a current PTSD diagnosis. METHODS: Pre-intervention data were analyzed from a subset (N = 43) of women in SUD residential treatment recruited for a mindfulness-based intervention efficacy clinical trial. Participants diagnosed with PTSD (n = 14) or not (n = 29) performed a task which involved attending to the somatic and visceral sensations of the breathing cycle (interoception) while undergoing a functional MRI (fMRI) scan. FMRI analysis employed independent components analysis and dual regression. First, we assessed differences in functional connectivity of interoception-modulated functional networks among those with and without PTSD. Second, we tested associations between network strength and lifetime sexual violence exposure across all participants on networks that showed significant group differences. RESULTS: PTSD diagnosis was associated with reduced functional connectivity of an orbitofrontal network with the precuneus, mid-posterior insula, lateral prefrontal cortex and angular gyrus. OFC network strength was inversely associated with sexual violence exposure over-and-above the contribution of PTSD status alone. CONCLUSIONS: Our findings provide a novel network-level account of brain activity associated with PTSD among women with SUDs, which may inform treatment response in this subpopulation.
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spelling pubmed-67288792019-09-12 Sexual trauma history is associated with reduced orbitofrontal network strength in substance-dependent women Poppa, Tasha Droutman, Vita Amaro, Hortensia Black, David Arnaudova, Inna Monterosso, John Neuroimage Clin Regular Article AIM: Substance use disorders (SUDs) are highly comorbid with post-traumatic stress disorder (PTSD). PTSD-SUD comorbidity is associated with greater functional impairments and relapse risk. Women with SUDs experience markedly higher rates of trauma and PTSD compared to men with SUDs, particularly due to sexual and domestic abuse. Despite the strong association between trauma exposure and SUDs, the neurobiological correlates are understudied, particularly among females with SUDs. However, there is indication of abnormal somatic and interoceptive processing in women with PTSD. The present study examines interoception-linked differences in intrinsic brain networks in a group of women with SUDs and varying histories of trauma exposure, some of whom have a current PTSD diagnosis. METHODS: Pre-intervention data were analyzed from a subset (N = 43) of women in SUD residential treatment recruited for a mindfulness-based intervention efficacy clinical trial. Participants diagnosed with PTSD (n = 14) or not (n = 29) performed a task which involved attending to the somatic and visceral sensations of the breathing cycle (interoception) while undergoing a functional MRI (fMRI) scan. FMRI analysis employed independent components analysis and dual regression. First, we assessed differences in functional connectivity of interoception-modulated functional networks among those with and without PTSD. Second, we tested associations between network strength and lifetime sexual violence exposure across all participants on networks that showed significant group differences. RESULTS: PTSD diagnosis was associated with reduced functional connectivity of an orbitofrontal network with the precuneus, mid-posterior insula, lateral prefrontal cortex and angular gyrus. OFC network strength was inversely associated with sexual violence exposure over-and-above the contribution of PTSD status alone. CONCLUSIONS: Our findings provide a novel network-level account of brain activity associated with PTSD among women with SUDs, which may inform treatment response in this subpopulation. Elsevier 2019-08-06 /pmc/articles/PMC6728879/ /pubmed/31472330 http://dx.doi.org/10.1016/j.nicl.2019.101973 Text en © 2019 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Regular Article
Poppa, Tasha
Droutman, Vita
Amaro, Hortensia
Black, David
Arnaudova, Inna
Monterosso, John
Sexual trauma history is associated with reduced orbitofrontal network strength in substance-dependent women
title Sexual trauma history is associated with reduced orbitofrontal network strength in substance-dependent women
title_full Sexual trauma history is associated with reduced orbitofrontal network strength in substance-dependent women
title_fullStr Sexual trauma history is associated with reduced orbitofrontal network strength in substance-dependent women
title_full_unstemmed Sexual trauma history is associated with reduced orbitofrontal network strength in substance-dependent women
title_short Sexual trauma history is associated with reduced orbitofrontal network strength in substance-dependent women
title_sort sexual trauma history is associated with reduced orbitofrontal network strength in substance-dependent women
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6728879/
https://www.ncbi.nlm.nih.gov/pubmed/31472330
http://dx.doi.org/10.1016/j.nicl.2019.101973
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