Brain Function Network and Young Adult Smokers: A Graph Theory Analysis Study

Cigarette smoking is associated with abnormalities in the widespread inter-regional functional connectivity of the brain. However, few studies focused on the abnormalities in the topological organization of brain functional networks in young smokers. In the current study, resting-state functional magnetic resonance images were acquired from 30 young male smokers and 32 age-, gender-, and education-matched healthy male nonsmokers. A functional network was constructed by calculating the Pearson correlation coefficients among 246 subregions in the human Brainnetome Atlas. The topological parameters were compared between smokers and nonsmokers. The results showed that the functional network of both young smokers and nonsmokers had small-world topology. Compared to nonsmokers, young smokers exhibited a decreased clustering coefficient (C(p)) and local network efficiency (E(local)). C(p) and E(local) were negatively correlated with the duration of cigarette use. In addition, increased nodal efficiency (E(nodal)) was mainly located in the prefrontal cortex (PFC), cingulate gyrus, insula, and caudate. Decreased connectivities among the PFC, cingulate gyrus, insula, basal ganglia (of specific node), and thalamus were also observed. In sum, we revealed the abnormal topological organization of brain functional networks in young smokers, which may improve our understanding of the neural mechanism of young smokers from a brain functional network topological organization perspective.