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Changes in triggering of ST-elevation myocardial infarction by particulate air pollution in Monroe County, New York over time: a case-crossover study

BACKGROUND: Previous studies have reported that fine particle (PM(2.5)) concentrations triggered ST elevation myocardial infarctions (STEMI). In Rochester, NY, multiple air quality policies and economic changes/influences from 2008 to 2013 led to decreased concentrations of PM(2.5) and its major con...

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Autores principales: Wang, Meng, Hopke, Philip K., Masiol, Mauro, Thurston, Sally W., Cameron, Scott, Ling, Frederick, van Wijngaarden, Edwin, Croft, Daniel, Squizzato, Stefania, Thevenet-Morrison, Kelly, Chalupa, David, Rich, David Q.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6728968/
https://www.ncbi.nlm.nih.gov/pubmed/31492149
http://dx.doi.org/10.1186/s12940-019-0521-3
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author Wang, Meng
Hopke, Philip K.
Masiol, Mauro
Thurston, Sally W.
Cameron, Scott
Ling, Frederick
van Wijngaarden, Edwin
Croft, Daniel
Squizzato, Stefania
Thevenet-Morrison, Kelly
Chalupa, David
Rich, David Q.
author_facet Wang, Meng
Hopke, Philip K.
Masiol, Mauro
Thurston, Sally W.
Cameron, Scott
Ling, Frederick
van Wijngaarden, Edwin
Croft, Daniel
Squizzato, Stefania
Thevenet-Morrison, Kelly
Chalupa, David
Rich, David Q.
author_sort Wang, Meng
collection PubMed
description BACKGROUND: Previous studies have reported that fine particle (PM(2.5)) concentrations triggered ST elevation myocardial infarctions (STEMI). In Rochester, NY, multiple air quality policies and economic changes/influences from 2008 to 2013 led to decreased concentrations of PM(2.5) and its major constituents (SO(4)(2−), NO(3)(−), elemental and primary organic carbon). This study examined whether the rate of STEMI associated with increased ambient gaseous and PM component concentrations was different AFTER these air quality policies and economic changes (2014–2016), compared to DURING (2008–2013) and BEFORE these polices and changes (2005–2007). METHODS: Using 921 STEMIs treated at the University of Rochester Medical Center (2005–2016) and a case-crossover design, we examined whether the rate of STEMI associated with increased PM(2.5), ultrafine particles (UFP, < 100 nm), accumulation mode particles (AMP, 100-500 nm), black carbon, SO(2), CO, and O(3) concentrations in the previous 1–72 h was modified by the time period related to these pollutant source changes (BEFORE, DURING, AFTER). RESULTS: Each interquartile range (3702 particles/cm(3)) increase in UFP concentration in the previous 1 h was associated with a 12% (95% CI = 3%, 22%) increase in the rate of STEMI. The effect size was larger in the AFTER period (26%) than the DURING (5%) or BEFORE periods (9%). There were similar patterns for black carbon and SO(2). CONCLUSIONS: An increased rate of STEMI associated with UFP and other pollutant concentrations was higher in the AFTER period compared to the BEFORE and DURING periods. This may be due to changes in PM composition (e.g. higher secondary organic carbon and particle bound reactive oxygen species) following these air quality policies and economic changes. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12940-019-0521-3) contains supplementary material, which is available to authorized users.
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spelling pubmed-67289682019-09-12 Changes in triggering of ST-elevation myocardial infarction by particulate air pollution in Monroe County, New York over time: a case-crossover study Wang, Meng Hopke, Philip K. Masiol, Mauro Thurston, Sally W. Cameron, Scott Ling, Frederick van Wijngaarden, Edwin Croft, Daniel Squizzato, Stefania Thevenet-Morrison, Kelly Chalupa, David Rich, David Q. Environ Health Research BACKGROUND: Previous studies have reported that fine particle (PM(2.5)) concentrations triggered ST elevation myocardial infarctions (STEMI). In Rochester, NY, multiple air quality policies and economic changes/influences from 2008 to 2013 led to decreased concentrations of PM(2.5) and its major constituents (SO(4)(2−), NO(3)(−), elemental and primary organic carbon). This study examined whether the rate of STEMI associated with increased ambient gaseous and PM component concentrations was different AFTER these air quality policies and economic changes (2014–2016), compared to DURING (2008–2013) and BEFORE these polices and changes (2005–2007). METHODS: Using 921 STEMIs treated at the University of Rochester Medical Center (2005–2016) and a case-crossover design, we examined whether the rate of STEMI associated with increased PM(2.5), ultrafine particles (UFP, < 100 nm), accumulation mode particles (AMP, 100-500 nm), black carbon, SO(2), CO, and O(3) concentrations in the previous 1–72 h was modified by the time period related to these pollutant source changes (BEFORE, DURING, AFTER). RESULTS: Each interquartile range (3702 particles/cm(3)) increase in UFP concentration in the previous 1 h was associated with a 12% (95% CI = 3%, 22%) increase in the rate of STEMI. The effect size was larger in the AFTER period (26%) than the DURING (5%) or BEFORE periods (9%). There were similar patterns for black carbon and SO(2). CONCLUSIONS: An increased rate of STEMI associated with UFP and other pollutant concentrations was higher in the AFTER period compared to the BEFORE and DURING periods. This may be due to changes in PM composition (e.g. higher secondary organic carbon and particle bound reactive oxygen species) following these air quality policies and economic changes. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12940-019-0521-3) contains supplementary material, which is available to authorized users. BioMed Central 2019-09-06 /pmc/articles/PMC6728968/ /pubmed/31492149 http://dx.doi.org/10.1186/s12940-019-0521-3 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Wang, Meng
Hopke, Philip K.
Masiol, Mauro
Thurston, Sally W.
Cameron, Scott
Ling, Frederick
van Wijngaarden, Edwin
Croft, Daniel
Squizzato, Stefania
Thevenet-Morrison, Kelly
Chalupa, David
Rich, David Q.
Changes in triggering of ST-elevation myocardial infarction by particulate air pollution in Monroe County, New York over time: a case-crossover study
title Changes in triggering of ST-elevation myocardial infarction by particulate air pollution in Monroe County, New York over time: a case-crossover study
title_full Changes in triggering of ST-elevation myocardial infarction by particulate air pollution in Monroe County, New York over time: a case-crossover study
title_fullStr Changes in triggering of ST-elevation myocardial infarction by particulate air pollution in Monroe County, New York over time: a case-crossover study
title_full_unstemmed Changes in triggering of ST-elevation myocardial infarction by particulate air pollution in Monroe County, New York over time: a case-crossover study
title_short Changes in triggering of ST-elevation myocardial infarction by particulate air pollution in Monroe County, New York over time: a case-crossover study
title_sort changes in triggering of st-elevation myocardial infarction by particulate air pollution in monroe county, new york over time: a case-crossover study
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6728968/
https://www.ncbi.nlm.nih.gov/pubmed/31492149
http://dx.doi.org/10.1186/s12940-019-0521-3
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