Prexasertib treatment induces homologous recombination deficiency and synergizes with olaparib in triple-negative breast cancer cells

BACKGROUND: Breast cancer remains as one of the most lethal types of cancer in women. Among various subtypes, triple-negative breast cancer (TNBC) is the most aggressive and hard to treat type of breast cancer. Mechanistically, increased DNA repair and cell cycle checkpoint activation remain as the...

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Detalles Bibliográficos
Autores principales: Mani, Chinnadurai, Jonnalagadda, Shirisha, Lingareddy, Jojireddy, Awasthi, Sanjay, Gmeiner, William H., Palle, Komaraiah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6729044/
https://www.ncbi.nlm.nih.gov/pubmed/31492187
http://dx.doi.org/10.1186/s13058-019-1192-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6729044/
https://www.ncbi.nlm.nih.gov/pubmed/31492187
http://dx.doi.org/10.1186/s13058-019-1192-2

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