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Measurement of serum irisin in the different stages of chronic kidney disease
BACKGROUND: Irisin is a myokine that regulates energy metabolism by inducing browning of adipose tissue. The aim of this study was to evaluate the relationship between irisin level and biochemical parameters of chronic kidney disease (CKD) patients in stage 2 and stage 4. METHODS: The research was a...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Babol University of Medical Sciences
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6729156/ https://www.ncbi.nlm.nih.gov/pubmed/31558994 http://dx.doi.org/10.22088/cjim.10.3.314 |
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author | Sadeghi Shad, Javad Akbari, Roghayeh Qujeq, Durdi Hajian-Tilaki, Karimollah |
author_facet | Sadeghi Shad, Javad Akbari, Roghayeh Qujeq, Durdi Hajian-Tilaki, Karimollah |
author_sort | Sadeghi Shad, Javad |
collection | PubMed |
description | BACKGROUND: Irisin is a myokine that regulates energy metabolism by inducing browning of adipose tissue. The aim of this study was to evaluate the relationship between irisin level and biochemical parameters of chronic kidney disease (CKD) patients in stage 2 and stage 4. METHODS: The research was a cross-sectional study; the study population included patients with CKD who were over 18 years of age, included 90 individuals with CKD, of these participants, 45 were in the second stage of the CKD while the other 45 subjects were in the fourth stage. Serum irisin concentration plus the level of glucose (Glu), urea, creatinine (Cr) and hemoglobin (Hb) were measured. RESULTS: In the present study, the serum irisin level of patients in stage 4 was significantly reduced (13.00 ng / ml) compared with patients in stage 2(21.41 ng / ml). CONCLUSION: With the progression of CKD from stage 2 to stage 4, parameters such as serum Cr, TG, LDL, FBS, BUN and urea levels significantly increased. Inversely, factors such as irisin, GFR, Alb, HDL and Hb levels significantly decreased. These findings suggest that irisin may be involved in the regulation of biochemical factor levels in CKD patients through the progression from stage 2 to stage 4. |
format | Online Article Text |
id | pubmed-6729156 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Babol University of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-67291562019-09-26 Measurement of serum irisin in the different stages of chronic kidney disease Sadeghi Shad, Javad Akbari, Roghayeh Qujeq, Durdi Hajian-Tilaki, Karimollah Caspian J Intern Med Original Article BACKGROUND: Irisin is a myokine that regulates energy metabolism by inducing browning of adipose tissue. The aim of this study was to evaluate the relationship between irisin level and biochemical parameters of chronic kidney disease (CKD) patients in stage 2 and stage 4. METHODS: The research was a cross-sectional study; the study population included patients with CKD who were over 18 years of age, included 90 individuals with CKD, of these participants, 45 were in the second stage of the CKD while the other 45 subjects were in the fourth stage. Serum irisin concentration plus the level of glucose (Glu), urea, creatinine (Cr) and hemoglobin (Hb) were measured. RESULTS: In the present study, the serum irisin level of patients in stage 4 was significantly reduced (13.00 ng / ml) compared with patients in stage 2(21.41 ng / ml). CONCLUSION: With the progression of CKD from stage 2 to stage 4, parameters such as serum Cr, TG, LDL, FBS, BUN and urea levels significantly increased. Inversely, factors such as irisin, GFR, Alb, HDL and Hb levels significantly decreased. These findings suggest that irisin may be involved in the regulation of biochemical factor levels in CKD patients through the progression from stage 2 to stage 4. Babol University of Medical Sciences 2019 /pmc/articles/PMC6729156/ /pubmed/31558994 http://dx.doi.org/10.22088/cjim.10.3.314 Text en This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Sadeghi Shad, Javad Akbari, Roghayeh Qujeq, Durdi Hajian-Tilaki, Karimollah Measurement of serum irisin in the different stages of chronic kidney disease |
title | Measurement of serum irisin in the different stages of chronic kidney disease |
title_full | Measurement of serum irisin in the different stages of chronic kidney disease |
title_fullStr | Measurement of serum irisin in the different stages of chronic kidney disease |
title_full_unstemmed | Measurement of serum irisin in the different stages of chronic kidney disease |
title_short | Measurement of serum irisin in the different stages of chronic kidney disease |
title_sort | measurement of serum irisin in the different stages of chronic kidney disease |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6729156/ https://www.ncbi.nlm.nih.gov/pubmed/31558994 http://dx.doi.org/10.22088/cjim.10.3.314 |
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