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Dexmedetomidine protects H9c2 cardiomyocytes against oxygen-glucose deprivation/reoxygenation-induced intracellular calcium overload and apoptosis through regulating FKBP12.6/RyR2 signaling

PURPOSE: Intracellular calcium ([Ca(2+)]i) overload is a major cause of cell injury during myocardial ischemia/reperfusion (I/R). Dexmedetomidine (DEX) has been shown to exert anti-inﬂammatory and organ protective effects. This study aimed to investigate whether pretreatment with DEX could protect H...

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Detalles Bibliográficos
Autores principales:	Yuan, Mei, Meng, Xiao-Wen, Ma, Jiao, Liu, Hong, Song, Shao-Yong, Chen, Qing-Cai, Liu, Hua-Yue, Zhang, Juan, Song, Nan, Ji, Fu-Hai, Peng, Ke
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2019
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6730549/ https://www.ncbi.nlm.nih.gov/pubmed/31564830 http://dx.doi.org/10.2147/DDDT.S219533

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