CRISPR DNA base editors with reduced RNA off-target and self-editing activities

Cytosine or adenine base editors (CBEs or ABEs) can introduce specific DNA C-to-T or A-to-G alterations(1–4). However, we recently demonstrated that they can also induce widespread guide RNA-independent RNA base edits(5) and created SElective Curbing of Unwanted RNA Editing (SECURE)-BE3 variants tha...

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Detalles Bibliográficos
Autores principales: Grünewald, Julian, Zhou, Ronghao, Iyer, Sowmya, Lareau, Caleb A., Garcia, Sara P., Aryee, Martin J., Joung, J. Keith
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6730565/
https://www.ncbi.nlm.nih.gov/pubmed/31477922
http://dx.doi.org/10.1038/s41587-019-0236-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6730565/
https://www.ncbi.nlm.nih.gov/pubmed/31477922
http://dx.doi.org/10.1038/s41587-019-0236-6

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