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CRISPR DNA base editors with reduced RNA off-target and self-editing activities
Cytosine or adenine base editors (CBEs or ABEs) can introduce specific DNA C-to-T or A-to-G alterations(1–4). However, we recently demonstrated that they can also induce widespread guide RNA-independent RNA base edits(5) and created SElective Curbing of Unwanted RNA Editing (SECURE)-BE3 variants tha...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6730565/ https://www.ncbi.nlm.nih.gov/pubmed/31477922 http://dx.doi.org/10.1038/s41587-019-0236-6 |