BCOR mutation and TLS-ERG expression in acute myeloid leukemia with monoclonal immunoglobulinemia

Acute myeloid leukemia (AML) originates from the abnormal clonal proliferation of myeloblasts. Immunoglobulin is secreted by B cells. AML with monoclonal antibody often indicates a poor prognosis. Here we report a case of BCOR mutation and TLS-ERG expression in AML with monoclonal immunoglobulinemia...

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Autores principales: Jin, Jingxia, Luo, Shuna, Ye, XingNong, Huang, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6730603/
https://www.ncbi.nlm.nih.gov/pubmed/31564896
http://dx.doi.org/10.2147/OTT.S218805
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author Jin, Jingxia
Luo, Shuna
Ye, XingNong
Huang, Jian
author_facet Jin, Jingxia
Luo, Shuna
Ye, XingNong
Huang, Jian
author_sort Jin, Jingxia
collection PubMed
description Acute myeloid leukemia (AML) originates from the abnormal clonal proliferation of myeloblasts. Immunoglobulin is secreted by B cells. AML with monoclonal antibody often indicates a poor prognosis. Here we report a case of BCOR mutation and TLS-ERG expression in AML with monoclonal immunoglobulinemia. After chemotherapy, the patient achieved bone marrow complete remission. BCOR mutation and TLS-ERG fusion gene in patient's bone marrow were not detected, at the same time, peripheral blood monoclonal immunoglobulin also disappeared. BCOR mutation or TLS-ERG fusion gene expression is associated with poor prognosis, AML with monoclonal immunoglobulin may have the same prognostic significance.
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spelling pubmed-67306032019-09-27 BCOR mutation and TLS-ERG expression in acute myeloid leukemia with monoclonal immunoglobulinemia Jin, Jingxia Luo, Shuna Ye, XingNong Huang, Jian Onco Targets Ther Case Report Acute myeloid leukemia (AML) originates from the abnormal clonal proliferation of myeloblasts. Immunoglobulin is secreted by B cells. AML with monoclonal antibody often indicates a poor prognosis. Here we report a case of BCOR mutation and TLS-ERG expression in AML with monoclonal immunoglobulinemia. After chemotherapy, the patient achieved bone marrow complete remission. BCOR mutation and TLS-ERG fusion gene in patient's bone marrow were not detected, at the same time, peripheral blood monoclonal immunoglobulin also disappeared. BCOR mutation or TLS-ERG fusion gene expression is associated with poor prognosis, AML with monoclonal immunoglobulin may have the same prognostic significance. Dove 2019-09-02 /pmc/articles/PMC6730603/ /pubmed/31564896 http://dx.doi.org/10.2147/OTT.S218805 Text en © 2019 Jin et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Case Report
Jin, Jingxia
Luo, Shuna
Ye, XingNong
Huang, Jian
BCOR mutation and TLS-ERG expression in acute myeloid leukemia with monoclonal immunoglobulinemia
title BCOR mutation and TLS-ERG expression in acute myeloid leukemia with monoclonal immunoglobulinemia
title_full BCOR mutation and TLS-ERG expression in acute myeloid leukemia with monoclonal immunoglobulinemia
title_fullStr BCOR mutation and TLS-ERG expression in acute myeloid leukemia with monoclonal immunoglobulinemia
title_full_unstemmed BCOR mutation and TLS-ERG expression in acute myeloid leukemia with monoclonal immunoglobulinemia
title_short BCOR mutation and TLS-ERG expression in acute myeloid leukemia with monoclonal immunoglobulinemia
title_sort bcor mutation and tls-erg expression in acute myeloid leukemia with monoclonal immunoglobulinemia
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6730603/
https://www.ncbi.nlm.nih.gov/pubmed/31564896
http://dx.doi.org/10.2147/OTT.S218805
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AT yexingnong bcormutationandtlsergexpressioninacutemyeloidleukemiawithmonoclonalimmunoglobulinemia
AT huangjian bcormutationandtlsergexpressioninacutemyeloidleukemiawithmonoclonalimmunoglobulinemia

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