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Nasal sprayed particle deposition in a human nasal cavity under different inhalation conditions
Deposition of polydisperse particles representing nasal spray application in a human nasal cavity was performed under transient breathing profiles of sniffing, constant flow, and breath hold. The LES turbulence model was used to describe the fluid phase. Particles were introduced into the flow field...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6730903/ https://www.ncbi.nlm.nih.gov/pubmed/31490971 http://dx.doi.org/10.1371/journal.pone.0221330 |
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author | Calmet, Hadrien Inthavong, Kiao Eguzkitza, Beatriz Lehmkuhl, Oriol Houzeaux, Guillaume Vázquez, Mariano |
author_facet | Calmet, Hadrien Inthavong, Kiao Eguzkitza, Beatriz Lehmkuhl, Oriol Houzeaux, Guillaume Vázquez, Mariano |
author_sort | Calmet, Hadrien |
collection | PubMed |
description | Deposition of polydisperse particles representing nasal spray application in a human nasal cavity was performed under transient breathing profiles of sniffing, constant flow, and breath hold. The LES turbulence model was used to describe the fluid phase. Particles were introduced into the flow field with initial spray conditions, including spray cone angle, insertion angle, and initial velocity. Since nasal spray atomizer design determines the particle conditions, fifteen particle size distributions were used, each defined by a log-normal distribution with a different volume mean diameter (Dv50). Particle deposition in the anterior region was approximately 80% when Dv50 > 50μm, and this decreased to 45% as Dv50 decreased to 10μ m for constant and sniff breathing conditions. The decrease in anterior deposition was countered with increased deposition in the middle and posterior regions. The significance of increased deposition in the middle region for drug delivery shows there is potential for nasal delivered drugs to reach the highly vascularised mucosal walls in the main nasal passages. For multiple targeted deposition sites, an optimisation equation was introduced where deposition results of any two targeted sites could be combined and a weighting between 0 to 1 was applied to each targeted site, representing the relative importance of each deposition site. |
format | Online Article Text |
id | pubmed-6730903 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-67309032019-09-16 Nasal sprayed particle deposition in a human nasal cavity under different inhalation conditions Calmet, Hadrien Inthavong, Kiao Eguzkitza, Beatriz Lehmkuhl, Oriol Houzeaux, Guillaume Vázquez, Mariano PLoS One Research Article Deposition of polydisperse particles representing nasal spray application in a human nasal cavity was performed under transient breathing profiles of sniffing, constant flow, and breath hold. The LES turbulence model was used to describe the fluid phase. Particles were introduced into the flow field with initial spray conditions, including spray cone angle, insertion angle, and initial velocity. Since nasal spray atomizer design determines the particle conditions, fifteen particle size distributions were used, each defined by a log-normal distribution with a different volume mean diameter (Dv50). Particle deposition in the anterior region was approximately 80% when Dv50 > 50μm, and this decreased to 45% as Dv50 decreased to 10μ m for constant and sniff breathing conditions. The decrease in anterior deposition was countered with increased deposition in the middle and posterior regions. The significance of increased deposition in the middle region for drug delivery shows there is potential for nasal delivered drugs to reach the highly vascularised mucosal walls in the main nasal passages. For multiple targeted deposition sites, an optimisation equation was introduced where deposition results of any two targeted sites could be combined and a weighting between 0 to 1 was applied to each targeted site, representing the relative importance of each deposition site. Public Library of Science 2019-09-06 /pmc/articles/PMC6730903/ /pubmed/31490971 http://dx.doi.org/10.1371/journal.pone.0221330 Text en © 2019 Calmet et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Calmet, Hadrien Inthavong, Kiao Eguzkitza, Beatriz Lehmkuhl, Oriol Houzeaux, Guillaume Vázquez, Mariano Nasal sprayed particle deposition in a human nasal cavity under different inhalation conditions |
title | Nasal sprayed particle deposition in a human nasal cavity under different inhalation conditions |
title_full | Nasal sprayed particle deposition in a human nasal cavity under different inhalation conditions |
title_fullStr | Nasal sprayed particle deposition in a human nasal cavity under different inhalation conditions |
title_full_unstemmed | Nasal sprayed particle deposition in a human nasal cavity under different inhalation conditions |
title_short | Nasal sprayed particle deposition in a human nasal cavity under different inhalation conditions |
title_sort | nasal sprayed particle deposition in a human nasal cavity under different inhalation conditions |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6730903/ https://www.ncbi.nlm.nih.gov/pubmed/31490971 http://dx.doi.org/10.1371/journal.pone.0221330 |
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